Health / Medical Topics |
IFNAR1 wt Allele
Human IFNAR1 wild-type allele is located in the vicinity of 21q22.11 and is approximately 35 kb in length. This allele, which encodes interferon alpha/beta receptor 1 protein, is involved in tyrosine-kinase signal transduction and receptor mediation to regulate innate immune responses to viral infection. (NCI Thesaurus)
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A chemoimmunotherapy regimen consisting of interferon and dacarbazine used for the treatment of advanced-stage or metastatic malignant melanoma.