| Health / Medical Topics |
Insulin Receptor Substrate 4
Similar in function to IRS1 and IRS2; insulin receptor substrate 4 is a cytoplasmic protein that contains many potential tyrosine and serine/threonine phosphorylation sites. Tyrosine-phosphorylated IRS4 protein has been shown to associate with cytoplasmic signalling molecules that contain SH2 domains. The IRS4 protein is phosphorylated by the insulin receptor tyrosine kinase upon receptor stimulation. (NCI Thesaurus)
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