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INTRON
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I. (noun)
Sense 1
Meaning:
Sequence of a eukaryotic gene's DNA that is not translated into a protein
Synonyms:
intron; noncoding DNA
Classified under:
Hypernyms ("intron" is a kind of...):
deoxyribonucleic acid; desoxyribonucleic acid; DNA ((biochemistry) a long linear polymer found in the nucleus of a cell and formed from nucleotides and shaped like a double helix; associated with the transmission of genetic information)
Antonym:
exon (sequence of a gene's DNA that transcribes into protein structures)
Context examples:
A fusion gene (~2.5 kb) that results from a chromosomal translocation t(1;13)(p36;q14) which fuses intron 7 of the PAX7 gene with intron 1 of the FOXO1 gene.
(PAX7/FOXO1 Fusion Gene, NCI Thesaurus)
The splicing factor SF3b is a multiprotein complex integral to the accurate excision of introns from pre-messenger RNA; the subunit SAP130 associates with U2 snRNP and is recruited to prespliceosomal complexes.
(Pladienolide Derivative E7107, NCI Thesaurus)
A fusion gene that results from a complex chromosomal rearrangement where inversion of 22q12 is followed by a translocation t(1;22)(p34;q12) that disrupts intron 3 of the UQCRH gene.
(PATZ1/UQCRH Fusion Gene, NCI Thesaurus)
A fusion gene that results from a chromosomal rearrangement of 9q34 which fuses the 5' half of the NUP214 gene with intron 1 of the ABL1 gene.
(NUP214/ABL1 Fusion Gene Variant 2, NCI Thesaurus)
This NA17 specific antigen, encoded by an intron sequence of N-acetylglucosaminyltransferase V (GnT-V) gene, is expressed in about 50% of melanomas.
(NA17.A2 Peptide Vaccine, NCI Thesaurus)
A fusion gene that results from a chromosomal rearrangement of 9q34 which fuses most of the NUP214 gene with intron 1 of the ABL1 gene.
(NUP214/ABL1 Fusion Gene Variant 1, NCI Thesaurus)
These sites are located in genes at intron to exon junctions at the 3' end of the intron.
(Acceptor Splice Site SNP, NCI Thesaurus)
A fusion gene (~2.1 kb) that results from a chromosomal inversion inv(2)(p21p23) which fuses exon 2 of the EML4 gene with approximately 115 nucleotides of intron 19 and exons 20-29 of the ALK gene.
(EML4/ALK Fusion Gene Variant 5b, NCI Thesaurus)
CETP B2 lacks a polymorphic TaqI restriction site in intron 1, present in CETP B1.
(CETP 2 Allele, NCI Thesaurus)
A four nucleotide repeat expansion in intron 1 resulting in 75 to 11000 CCTG repeats is associated with myotonic dystrophy type 2.
(CNBP wt Allele, NCI Thesaurus)
