ISWI

The Drosophila gene Imitation SWI (Iswi) encodes a DNA helicase involved in chromatin modeling. It contains a SNF2 related domain, a MYB DNA binding domain, a DEAD/DEAH box helicase, and a helicase C-terminal domain. Iswi is a component of NURF, a nucleosome remodeling complex that facilitates the perturbation of chromatin structure in an ATP-dependent manner. The hydrolysis of ATP during the remodeling of chromatin is mediated by Iswi. It is also a component of the ATP-utilizing chromatin assembly and remodeling factor ACF and of the chromatin accessibility complex CHRAC. This subunit serves as the energy-transducing component of chromatin-remodeling machines. NURF is composed of a 215 kD protein, Iswi, nurf-55, and nurf-38. Iswi belongs to the SNF2/RAD54 helicase family, SNF2L subfamily. (from FlyBase 0011604 and NCI) (NCI Thesaurus)

YOU MAY ALSO LIKE

Istodax

A drug used to treat cutaneous T-cell lymphoma in patients who have been treated with other anticancer drugs. It is also being…

Isthmus Uteri

An elongated constriction of the lower part of the uterus, located at the junction of the body of the uterus and the…

Isthmus

A narrow part inside the body that connects two larger structures.

Isthmic Segment of the Fallopian Tube

The muscular portion of the fallopian tube that continues to narrow as it connects to the uterus.

Issue with Displayed Error Message

Issue associated with error messages that are undecipherable or which fail to prompt the user toward appropriate corrective action.

Issue

One of a series of documents that are published periodically.