| Health / Medical Topics |
JAK2 Gene Mutation
Mutation of the Janus 2 kinase gene at chromosome 9. It is seen in most patients with polycythemia vera and less frequently in other myeloproliferative neoplasms. (NCI Thesaurus)
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Human JAK1 wild-type allele is located within 1p32.3-p31.3 and is approximately 53 kb in length. This allele, which encodes tyrosine-protein kinase JAK1…
This gene plays a role in signal transduction.
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An orally bioavailable inhibitor of Janus-associated kinases (JAK), with potential antineoplastic activity. Upon oral administration, INCB047986 specifically binds to and inhibits the…
Human JAG2 wild-type allele is located in the vicinity of 14q32 and is approximately 27 kb in length. This allele, which encodes…
