Health / Medical Topics

    KRT18 wt Allele

    Human KRT18 wild-type allele is located in the vicinity of 12q13 and is approximately 4 kb in length. This allele, which encodes keratin, type I cytoskeletal 18 protein, is involved in both the negative regulation of apoptosis and intermediate filament structure. Mutations in the gene are associated with cryptogenic cirrhosis. (NCI Thesaurus)




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