Ku Subunit Gene

Ku Subunit Genes encode tightly-associated 70-kDa Ku70 Protein and 80-kDa Ku80 Protein subunits of heterodimeric DNA-binding Ku Protein, a DNA damage repair complex that, with the 470-kDa catalytic DNA-PKcs subunit forms DNA-dependent protein kinase, binds and repairs double-stranded DNA breaks, facilitates repair by nonhomologous end-joining, and is involved in V(D)J recombination. Ku also binds to DNA ends with a telomere binding protein and mediates telomere capping to prevent fusion of chromosome ends and genetic instability. KU70 and KU80 form a dyad-symmetrical ring molecule that encircles duplex DNA. Ku is identical to DNA helicase II, an ATP-dependent DNA unwinding enzyme. (NCI Thesaurus)

YOU MAY ALSO LIKE

Ku Protein

Encoded by Ku Subunit Genes, tightly-associated 70-kDa Ku70 Protein and 80-kDa Ku80 Protein are subunits of heterodimeric DNA-binding Ku Protein, a DNA…

KTN1 wt Allele

Human KTN1 wild-type allele is located in the vicinity of 14q22.1 and is approximately 104 kb in length. This allele, which encodes…

KTN1 Gene

This gene plays a role in kinesin function.

KSR2 wt Allele

Human KSR2 wild-type allele is located within 12q24.22-q24.23 and is approximately 517 kb in length. This allele, which encodes kinase suppressor of…

KSR2 Gene

This gene plays a role in the regulation of MAP kinase kinase activity.

KSR1 wt Allele

Human KSR1 wild-type allele is located in the vicinity of 17q11.1 and is approximately 77 kb in length. This allele, which encodes…