Light-Emitting Oncolytic Vaccinia Virus GL-ONC1

An attenuated oncolytic vaccinia virus encoding the light-emitting fusion protein Renilla luciferase-Aequorea green fluorescent protein (RUC-GFP) with potential bioluminescent and antineoplastic activities. Upon administration, light-emitting oncolytic vaccinia virus GL-ONC1 specifically enters tumor cells due to the permeable nature of the tumor vasculature. Once inside the cell, the virus replicates, resulting in tumor cell lysis and the release of mature viral particles into the tumor microenvironment. Released viral particles may then infect and destroy neighboring tumor cells. In addition, the release of tumor-associated antigens (TAAs) by lysed tumor cells into the bloodstream may activate the immune system to mount a cytotoxic T lymphocyte (CTL) response against the tumor. The expression of RUC-GFP by this agent allows for both detection and monitoring of virally infected tumor cells in vivo and vitro with luciferase-mediated bioluminescence imaging and fluorescence imaging techniques. (NCI Thesaurus)

YOU MAY ALSO LIKE

Light-emitting diode therapy

Treatment with drugs that become active and may kill cancer cells when exposed to light. Light-emitting diode therapy is type of photodynamic…

Light Work

Work tasks that require little physical or mental effort.

Light therapy

The treatment of disease with certain types of light. Light therapy can use lasers, LED, fluorescent lamps, and ultraviolet or infrared…

Light Scattering

Dispersal of a beam of light into a range of directions as a result of physical interactions.

Light Mineral Oil

A low viscosity liquid by-product of the distillation of petroleum consisting of a mixture of alkanes in the C15 to C40…

Light Microscopy

Light Microscopy is a technique for producing visible images of structures or details which are too small to be otherwise seen by…