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LINKAGE
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I. (noun)
Sense 1
Meaning:
The act of linking things together
Classified under:
Nouns denoting acts or actions
Hypernyms ("linkage" is a kind of...):
attachment; fastening (the act of fastening things together)
Derivation:
link (connect, fasten, or put together two or more pieces)
Sense 2
Meaning:
A mechanical system of rods or springs or pivots that transmits power or motion
Classified under:
Nouns denoting man-made objects
Hypernyms ("linkage" is a kind of...):
mechanical system (a system of elements that interact on mechanical principles)
Derivation:
link (be or become joined or united or linked)
Sense 3
Meaning:
(genetics) traits that tend to be inherited together as a consequence of an association between their genes; all of the genes of a given chromosome are linked (where one goes they all go)
Synonyms:
gene linkage; linkage
Classified under:
Nouns denoting attributes of people and objects
Hypernyms ("linkage" is a kind of...):
hereditary pattern; inheritance ((genetics) attributes acquired via biological heredity from the parents)
Domain category:
genetic science; genetics (the branch of biology that studies heredity and variation in organisms)
Sense 4
Meaning:
An associative relation
Classified under:
Nouns denoting relations between people or things or ideas
Hypernyms ("linkage" is a kind of...):
connectedness; connection; connexion (a relation between things or events (as in the case of one causing the other or sharing features with it))
Hyponyms (each of the following is a kind of "linkage"):
link; nexus (the means of connection between things linked in series)
Derivation:
link (make a logical or causal connection)
Context examples:
The linkage system in SGN-LIV1A is highly stable in plasma, resulting in cytotoxic specificity against LIV-1-positive cells.
(Anti-LIV-1 Monoclonal Antibody-MMAE Conjugate SGN-LIV1A, NCI Thesaurus)
A direct linkage between an artery and a vein.
(Arteriovenous Shunt, NCI Thesaurus)
Melphalan alkylates DNA at the N7 position of guanine and induces DNA inter-strand cross-linkages, resulting in the inhibition of DNA and RNA synthesis and cytotoxicity against both dividing and non-dividing tumor cells.
(Melphalan, NCI Thesaurus)
After intratumoral injection, cisplatin alkylates guanine nucleosides in DNA, and causes DNA-DNA or DNA-protein cross-linkages, thereby preventing DNA replication and resulting in tumor cell growth inhibition and apoptosis.
(Cisplatin-E Therapeutic Implant, NCI Thesaurus)
An integrated physical and genetic linkage map of the human genome produced by the Centre d'Etude du Polymorphisme Humain (CEPH) and the Genethon research laboratories.
(CEPH/Genethon Map, NCI Thesaurus)
A family of hydrolases that cleaves alpha-linkages in polysaccharides, such as starch and glycogen, and yield glucose and maltose.
(Alpha-Amylase, NCI Thesaurus)
Inactivation of PBPs interferes with the cross-linkage of peptidoglycan chains necessary for bacterial cell wall strength and rigidity, resulting in a reduction of bacterial cell wall stability and cell lysis.
(Cefepime Hydrochloride, NCI Thesaurus)
Melphalan alkylates DNA at the N7 position of guanine residues and induces DNA intra- and inter-strand cross-linkages.
(Melphalan-Flufenamide Prodrug, NCI Thesaurus)
The linkage between duplicated sister DNAs is established during S phase and maintained throughout G2 phase (cohesion).
(Mitotic Sister Chromatid Cohesion, NCI Thesaurus)
A glycosylation site is an amino acid residue within a peptide that accepts oligosaccharide via amide linkage, specifically through amide nitrogen of asparagine via N-acetylglucosamine, as one of the post-translational modifications.
(N-Glycosylation Site, NCI Thesaurus)
