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Long QT Syndrome
Definition 1
A ventricular arrhythmia characterized by a long QT interval, and accompanied by syncopal episodes sometimes leading to sudden death due to paroxysmal ventricular arrhythmia. This arrhythmia is associated with a prolongation of repolarization following depolarization of the cardiac ventricles. The prolongation of the Q-T interval combined with torsades de pointes manifests as several different forms; some may be acquired or congenital; some may lead to serious arrhythmia and sudden cardiac death. (NCI Thesaurus)
Definition 2
A syndrome characterized by history of syncopal episodes and a long QT interval, sometimes leading to sudden death (DEATH, SUDDEN, CARDIAC) due to paroxysmal ventricular arrhythmia. A form associated with autosomal recessive inheritance and congenital deafness is called the JERVELL-LANGE NIELSEN SYNDROME. An autosomal dominant form without deafness is called the ROMANO-WARD SYNDROME. (NLM, Medical Subject Headings)
Definition 3
Long QT Syndrome includes prolongation of the corrected QT interval beyond 440 ms for adult males, 460 ms for adult females and 50 ms in the presence of ventricular depolarization abnormalities (i.e., bundle branch blocks or IVCB more than 120 ms. A normal QT interval in a resting ECG with a failure to shorten with an increase in heart rate qualifies as Long QT Syndrome. (NCI Thesaurus/CDISC)
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