Loperamide hydrochloride

Pronunciation

Definition 1

A drug used to treat diarrhea. Loperamide hydrochloride slows the movement of the muscles in the small intestine to allow more water to be taken out of the feces (waste matter) and more nutrients to be absorbed. Also called Imodium. (NCI Dictionary)

Definition 2

The hydrochloride salt form of loperamide, a synthetic, piperidine derivative and opioid agonist with antidiarrheal activity. Loperamide acts on the mu-receptors in the intestinal mucosa. This leads to a decrease in gastrointestinal motility by decreasing the circular and longitudinal smooth muscle activity of the intestinal wall. This slows intestinal transit and allows for more water and electrolyte absorption from the intestines. Loperamide is not significantly absorbed from the gut and does not cross the blood-brain barrier. Therefore it has no central nervous system effects. (NCI Thesaurus)

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