Lymphocyte Antigen 6 Complex, Locus E

LY6E gene encodes a cell surface protein containing 20 N-terminal amino acids corresponding to a signal peptide and an extracellular sequence of 111 amino acids. LY6E protein shares some homology with CD59 and some growth factor receptors; highest homology is with the murine LY6 multigene family of small cysteine-rich proteins differentially expressed in several hematopoietic cell lines and with apparent signal transduction function. RIGE is the closest human LY6 family homolog. RIGE expression is not restricted to myeloid differentiation; it is also present in thymocytes and other tissues at different levels. By Northern blot analysis, the highest expression of RIGE was found in liver, kidney, and ovary in addition to peripheral blood leukocytes. (OMIM) (NCI Thesaurus)

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