Lymphomatoid granulomatosis

Pronunciation

Definition 1

Destructive growth of lymph cells, usually involving the lungs, skin, kidneys, and central nervous system. Grades I and II are not considered cancer, but grade III is considered a lymphoma. (NCI Dictionary)

Definition 2

An angiocentric and angiodestructive lymphoproliferative disease involving extranodal sites, comprised of Epstein-Barr virus (EBV)-positive B-cells admixed with reactive T-cells. Incidence is higher among adult males; patients with a history of immunodeficiency are at increased risk. The most common site of involvement is the lung; other common sites include brain, kidney, liver, and skin. Morphologically, three grades are recognized: grade I, II, and III. Grade III lymphomatoid granulomatosis should be approached clinically as a subtype of diffuse large B-cell lymphoma. (NCI Thesaurus)

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