Health / Medical Topics |
Lynch 1 Syndrome
A rare genetic neoplastic syndrome with an autosomal dominant pattern of inheritance but incomplete penetrance. It is associated with a greater than 70 % risk of developing colorectal carcinoma. It is caused by a mutation in one of the mismatch repair genes: MSH2, MLH1, MSH6 or PMS2. It usually manifests at age 50 or younger with multiple synchronous or metachronous colorectal carcinomas. Clinical course is rapidly progressive. Prognosis is variable with a high risk for the development of additional colorectal carcinomas. However, survival is significantly better than non-HNPCC carcinomas of equivalent stage. (NCI Thesaurus)
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Human LYN wild-type allele is located within 8q13 and is approximately 132 kb in length. This allele, which encodes tyrosine-protein kinase Lyn…
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This gene plays a role in signal transduction.
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Of or relating to the lymphatic vessels.
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The determination of the amount of lymphotactin present in a sample.
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A condition in which tissue or a limb becomes very swollen and thick, and changes color. It is caused by a…
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A method used to check the lymph system for disease. A radioactive substance that flows through the lymph ducts and can be…
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