Library / English Dictionary

MALEATE

Pronunciation (US):

(GB):

 I. (noun) 

Sense 1

Meaning:

A salt or ester of maleic acid; used as a nontricyclic antidepressant drug for psychomotor activation

Classified under:

Nouns denoting substances

Hypernyms ("maleate" is a kind of...):

antidepressant; antidepressant drug (any of a class of drugs used to treat depression; often have undesirable side effects)

ester (organic compound formed by reaction between an acid and an alcohol with elimination of water)

Credits

 Context examples: 

The maleate salt of methylergonovine, a semi-synthetic ergot alkaloid with vasoconstrictive and uterotonic effects.

(Methylergonovine Maleate, NCI Thesaurus)

Brompheniramine maleate, a propylamine antihistamine binds to and blocks H1 receptors thereby preventing the actions of histamine.

(Dimetapp, NCI Thesaurus)

A commercial combination preparation, by Biovail Pharmaceuticals, containing chlorpheniramine maleate, phenylephrine hydrochloride and methscopolamine nitrate used to relieve symptoms of cold and flu.

(DuraVent DA, NCI Thesaurus)

The maleate salt of acepromazine, a phenothiazine derivative with depressant effect on the central nervous system.

(Acepromazine Maleate, NCI Thesaurus)

The maleate salt of an indole ether quinazoline derivative with antineoplastic activities.

(Cediranib maleate, NCI Thesaurus)

The maleate salt form of enalapril, a dicarbocyl-containing peptide and angiotensin-converting enzyme (ACE) inhibitor with antihypertensive activity.

(Enalapril Maleate, NCI Thesaurus)

Also called rosiglitazone maleate.

(Avandia, NCI Dictionary)

Enalapril maleate is de-esterified within the cells into its active form enalaprilat that inhibits ACE, thereby prevents the formation of angiotensin II, and blocks angiotensin II mediated activities, including vasoconstriction and stimulation of aldosterone synthesis and secretion, which regulates extracellular sodium concentration.

(Enalapril Maleate/Hydrochlorothiazide, NCI Thesaurus)

Any of the commercial combination preparations, by Novartis, containing a combination of any of the following agents: the analgesic antipyretic acetaminophen, an antihistamine (chlorpheniramine maleate or brompheniramine maleate), the expectorant guaifenesin, the antitussive dextromethorphan maleate and/or the decongestant pseudoephedrine hydrochloride.

(Comtrex, NCI Thesaurus)

Pheniramine maleate binds to histamine H1 receptors, thereby inhibiting phospholipase A2 and production of endothelium-derived relaxing factor, nitric oxide.

(Pheniramine Maleate, NCI Thesaurus)