| Health / Medical Topics |
MANF wt Allele
Human MANF wild-type allele is located in the vicinity of 3p21.1 and is approximately 4 kb in length. This allele, which encodes mesencephalic astrocyte-derived neurotrophic factor protein, plays a role in both the modulation of GABA neurotransmission and the mediation of dopaminergic neuron survival. (NCI Thesaurus)
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This gene is involved in the regulation of both function and survival of dopaminergic neurons.
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