Library / English Dictionary

MEDIATE

Pronunciation (US):

(GB):

 I. (adjective) 

Sense 1

Meaning:

Acting through or dependent on an intervening agency

Example:

the disease spread by mediate as well as direct contact

Classified under:

Adjectives

Similar:

indirect (having intervening factors or persons or influences)

mediated (acting or brought about through an intervening agency)

Attribute:

immediacy; immediateness (lack of an intervening or mediating agency)

Antonym:

immediate (having no intervening medium)

Derivation:

mediateness (the quality of being mediate)

Sense 2

Meaning:

Being neither at the beginning nor at the end in a series

Example:

the middle point on a line

Synonyms:

in-between; mediate; middle

Classified under:

Adjectives

Similar:

intermediate (lying between two extremes in time or space or state)

 II. (verb) 

Sense 1

Meaning:

Act between parties with a view to reconciling differences

Example:

He mediated a settlement

Synonyms:

arbitrate; intercede; intermediate; liaise; mediate

Classified under:

Verbs of telling, asking, ordering, singing

Hypernyms (to "mediate" is one way to...):

negociate; negotiate; talk terms (discuss the terms of an arrangement)

Sentence frames:

Somebody ----s
Somebody ----s PP

Sentence example:

Sam and Sue mediate

Derivation:

mediation (the act of intervening for the purpose of bringing about a settlement)

mediation (a negotiation to resolve differences that is conducted by some impartial party)

mediator (a negotiator who acts as a link between parties)

Sense 2

Meaning:

Occupy an intermediate or middle position or form a connecting link or stage between two others

Example:

mediate between the old and the new

Classified under:

Verbs of being, having, spatial relations

Hypernyms (to "mediate" is one way to...):

lie (be located or situated somewhere; occupy a certain position)

Sentence frame:

Something ----s

Credits

 Context examples: 

This work reveals sleep as a possible mediating pathway, the potential missing link between fish and intelligence.

(Weekly Fish Consumption Linked to Better Sleep, Higher IQ, The Titi Tudorancea Bulletin)

The key to the process is selectivity of the transport mechanism mediated by exosomes.

(Scientists successfully deliver “Trojan horse” catalysts into cancerous tumour cells to destroy them from within, Universities of Granada)

Experiments showed that the morphine-induced sensitivity wasn’t mediated through opioid receptors.

(Opioid Pain Relievers May Prolong Pain, NIH)

This allele, which encodes E3 ubiquitin-protein ligase MIB1 protein, plays a role in both ubiquitination and the regulation of Delta-mediated Notch signaling.

(MIB1 wt Allele, NCI Thesaurus)

They are often associated with microtubules and may play a role in cytoskeletal function and/or mediate movement of the cell or the organelles within the cell.

(Microfilament Protein, NLM, Medical Subject Headings)

MEK inhibitor GDC-0623 specifically inhibits mitogen-activated protein kinase kinase (MEK or MAP/ERK kinase), resulting in inhibition of growth factor-mediated cell signaling and tumor cell proliferation.

(MEK Inhibitor GDC-0623, NCI Thesaurus)

MEK inhibitor AZD8330 specifically inhibits mitogen-activated protein kinase kinase 1 (MEK or MAP/ERK kinase1), resulting in inhibition of growth factor-mediated cell signaling and tumor cell proliferation.

(MEK Inhibitor AZD8330, NCI Thesaurus)

Altogether, these IFN-g-mediated effects may result in an inhibition of tumor cell proliferation and tumor cell death.

(Adenovirus-Interferon-Gamma TG1042, NCI Thesaurus)

This gene plays a role in cell-mediated immunity and macrophage function.

(MIF Gene, NCI Thesaurus)

After intratumoral injection and adenovector-mediated gene transfer of MDA7 into tumor cells, the expressed MDA7 transgene may inhibit tumor cell proliferation and induce tumor cell apoptosis.

(Adenovector Encoding MDA7, NCI Thesaurus)