Medical Topics
An eastern North American perennial herb. A substance obtained from the root of the plant has been used in some cultures to… »
An herb native to islands in the South Pacific. Substances taken from the root have been used in some cultures to relieve… »
A monoclonal antibody that is being studied in the treatment of some types of cancer. Monoclonal antibodies are made in the laboratory… »
A substance that is being studied in the treatment of infections caused by fungi. It belongs to the family of drugs called… »
An idiopathic vascular disorder characterized by ischemic attacks in the fingers, toes, ears, or nose, associated with pain and pallor. The attacks… »
A set of symptoms characteristic of peripheral vascular disease, namely caused by an inappropriate response of the peripheral arteries in reaction to… »
An orally active, 1,2-benzisoxazole-containing, inhibitor of coagulation factor Xa (activated factor X) with anticoagulant activity. Razaxaban forms an isoxazole-ring opened, stable, benzamidine… »
The hydrochloride salt form of razaxaban, an orally active, 1,2-benzisoxazole-containing, inhibitor of coagulation factor Xa (activated factor X) with anticoagulant activity. Razaxaban… »
An orally bioavailable bis-dioxopiperazine and a derivative of the chelating agent ethylenediaminetetraacetic acid (EDTA) with antineoplastic, antiangiogenic, and antimetastatic activities. Razoxane specifically… »
A broad-spectrum carbapenem with activity against gram-positive bacteria, including methicillin-resistant S. aureus. »
This gene is involved in the regulation of cell differentiation, growth and proliferation. »
Human RB1 wild-type allele is located in the vicinity of 13q14.2 and is approximately 178 kb in length. This allele, which encodes… »
RB1-inducible coiled-coil protein 1 (1594 aa, ~183 kDa) is encoded by the human RB1CC1 gene. This protein is involved in the regulation… »
This gene is involved in the modulation of both the cell cycle and autophagy. »
Human RB1CC1 wild-type allele is located in the vicinity of 8q11 and is approximately 92 kb in length. This allele, which encodes… »
Encoded by human RBBP1L1 Gene, 803-amino acid 91 kD RBP1-Like Protein is similar to RBP1, containing a Tudor domain and an ARID… »
This gene is involved in the regulation of both transcription and cell proliferation. »
Human RBBP4 wild-type allele is located 1p35.1 and is approximately 35 kb in length. This allele, which encodes histone-binding protein RBBP4, plays… »
This gene is involved in cell cycle regulation. »
Human RBBP8 wild-type allele is located in the vicinity of 18q11.2 and is approximately 93 kb in length. This allele, which encodes… »
This gene is involved in the regulation of cellular proliferation and differentiation. »
Human RBBP9 wild-type allele is located in the vicinity of 20p11.2 and is approximately 11 kb in length. This allele, which encodes… »
A type of blood cell that is made in the bone marrow and found in the blood. RBCs contain a protein called… »
This gene plays a role in mRNA processing. »
Human RBFOX1 wild-type allele is located in the vicinity of 16p13.3 and is approximately 1694 kb in length. This allele, which encodes… »
Human RBL1 wild-type allele is located in the vicinity of 20q11.2 and is approximately 100 kb in length. This allele, which encodes… »
Human RBL2 wild-type allele is located in the vicinity of 16q12.2 and is approximately 57 kb in length. This allele, which encodes… »
This gene plays a role in RNA binding. »
Human RBM15 wild-type allele is located in the vicinity of 1p13 and is approximately 8 kb in length. This allele, which encodes… »
A fusion gene that results from a chromosomal translocation t(1;22)(p13;q13) which fuses the 5' portion of the RBM15 gene to the 3'… »
A fusion protein that is encoded by the RBM15/MKL1 fusion gene. This protein consists of most of the putative RNA-binding protein 15,… »
This gene is involved in both RNA splicing and mRNA stability. »
Human RBM38 wild-type allele is located in the vicinity of 20q13.31 and is approximately 18 kb in length. This allele, which encodes… »
Human RBM4 wild-type allele is located in the vicinity of 11q13 and is approximately 28 kb in length. This allele, which encodes… »
Human RBM5 wild-type allele is located in the vicinity of 3p21.3 and is approximately 30 kb in length. This allele, which encodes… »
Human RBM6 wild-type allele is located in the vicinity of 3p21.3 and is approximately 137 kb in length. This allele, which encodes… »
Widely expressed by human PLU-1 Gene (RBBP Family) at varying levels (highest in Sertoli cells), 1544-aa 176-kDa nuclear RBP2-Like Protein contains 3… »
Human RBX1 wild-type allele is located in the vicinity of 22q13.2 and is approximately 21 kb in length. This allele, which encodes… »
This gene is involved in modulation of protein phosphorylation. »
Human RCAN1 wild-type allele is located in the vicinity of 21q22.12 and is approximately 99 kb in length. This allele, which encodes… »
A recombinant retroviral virus derived from SR-A strain of Rous sarcoma virus carrying a constitutively active form of the AKT Gene. The… »
A recombinant retroviral virus derived from SR-A strain of Rous sarcoma virus carrying a human gene encoding the G12D mutant form of… »
Human RCN2 wild-type allele is located within 15q23 and is approximately 18 kb in length. This allele, which encodes reticulocalbin-2 protein, plays… »
Roland Morris Disability Questionnaire (RDQ) My appetite is not very good because of my back pain. »
Roland Morris Disability Questionnaire (RDQ) I avoid heavy jobs around the house because of my back. »
Roland Morris Disability Questionnaire (RDQ) I change position frequently to try and get my back comfortable. »
Roland Morris Disability Questionnaire (RDQ) I find it difficult to get out of a chair because of my back. »
Roland Morris Disability Questionnaire (RDQ) I find it difficult to turn over in bed because of my back. »
Roland Morris Disability Questionnaire (RDQ) I get dressed more slowly then usual because of my back. »
Roland Morris Disability Questionnaire (RDQ) Because of my back pain, I get dressed with help from someone else. »
Roland Morris Disability Questionnaire (RDQ) Because of my back, I try to get other people to do things for me. »
Roland Morris Disability Questionnaire (RDQ) Because of my back, I go upstairs more slowly than usual. »
Roland Morris Disability Questionnaire (RDQ) Because of my back, I have to hold on to something to get out of an easy… »
Roland Morris Disability Questionnaire (RDQ) Because of my back, I lie down to rest more often. »
Roland Morris Disability Questionnaire (RDQ) Because of my back pain, I am more irritable and bad tempered with people than usual. … »
Roland Morris Disability Questionnaire (RDQ) Because of my back, I am not doing any of the jobs that I usually do around… »
Roland Morris Disability Questionnaire (RDQ) I only stand for short periods of time because of my back. »
Roland Morris Disability Questionnaire (RDQ) I only walk short distances because of my back. »
Roland Morris Disability Questionnaire (RDQ) My back is painful almost all the time. »
Roland Morris Disability Questionnaire (RDQ) I sit down for most of the day because of my back. »
Roland Morris Disability Questionnaire (RDQ) I sleep less well because of my back. »
Roland Morris Disability Questionnaire (RDQ) I stay at home most of the time because of my back. »
Roland Morris Disability Questionnaire (RDQ) I stay in bed most of the time because of my back. »
Roland Morris Disability Questionnaire (RDQ) RDQ total derived score. »
Roland Morris Disability Questionnaire (RDQ) I have trouble putting on my socks (or stockings) because of the pain in my back. … »
Roland Morris Disability Questionnaire (RDQ) Because of my back, I try not to bend or kneel down. »
Roland Morris Disability Questionnaire (RDQ) Because of my back, I use a handrail to get upstairs. »
Roland Morris Disability Questionnaire (RDQ) I walk more slowly than usual because of my back. »
A question associated with the RDQ questionnaire. »
A surgical procedure to remove the remaining abnormal tissues from the body, not completely removed in an earlier attempt. »
An opposition to the flow of electric current resulting from inductance and capacitance (rather than resistance). »
To make active again or make something work again. In medicine, an infection or a disease is described as reactivated when it… »
A non-neoplastic proliferation of C-cells in the thyroid gland caused by external stimuli such as hypercalcemia and chronic lymphocytic thyroiditis. »
A benign, epidermal skin lesion characterized by overexpression of collagen during wound healing. »
Depression precipitated by events in a person's life. »
A measurement of the reactive lymphocytes in a biological specimen. »
The determination of the number of reactive lymphocytes present in a blood sample. »
The determination of the ratio of reactive lymphocytes compared to all lymphocytes present in a sample. The measurement may be expressed as… »
A type of unstable molecule that contains oxygen and that easily reacts with other molecules in a cell. A build up… »
A vessel in which a chemical reaction takes place or an electronic device designed to add reactance to a circuit. »
A type of data storage device which is manufactured with fixed contents. ROM is inherently non-volatile storage, retaining its contents even when… »
Permission that allows a user or program the ability to view information. »
The specific medical individual, usually a radiologist, who looks at and interprets a medical image. »
A device designed to capture data encoded on an object and convert it to a signal that can be input into a… »
One of the three possible ways of reading a nucleotide sequence. As the genetic code is read in nonoverlapping triplets (codons) there… »
A substance used to carry out a laboratory test. Reagents may be used in a chemical reaction to detect, measure, or… »
The lot number of the reagent. »
A data type comprised of fractional numbers. »
Any of the rational or irrational numbers. »
A modified polymerase chain reaction (PCR) technique in which DNA amplification is detected and quantified as the PCR reaction progresses, through the… »
Various XML file formats suitable for disseminating real-time information via subscription on the Internet. »
The National Institutes of Health will consider only two amendments to the initial grant application. Regardless of the number of amendments,… »
A coded value specifying the rationale for an activity or entity. »
The explanation why a particular action was rejected or denied. »
An explanation why a medical device product is exempt from direct part marking. »
The explanation why a summary was necessary for a clinical study. »
The reason that a subject was discontinued from a clinical trial. »
The reason why the problematic device has not been evaluated by the manufacturer. Examples include: device received in a condition which made… »
Terminology used in Individual Case Safety Reports to specify a reason for non-evaluation of a problematic medical product, section F3.3 of FDA… »
A rationale for executing a plan of action. »
The reason the treatment was administered. »
The reason the drug or therapy was temporarily ceased. »
The reason the treatment was not administered. »
A quinolinone derivative with anti-ulcer and anti-inflammatory activities. Rebamipide induces cyclooxygenase 2 (COX2) synthesis which results in an increase in endogenous prostaglandin… »
The tosylate salt of rebastinib, an orally bioavailable small-molecule inhibitor of multiple tyrosine kinases with potential antineoplastic activity. Rebastinib binds to and… »
A substance that is being studied in the treatment of cancer. It belongs to the family of drugs called antineoplastic antibiotics. … »
A substance that is being studied in the treatment of cancer. It belongs to the families of drugs called antitumor antibiotics and… »
A sulfhydryl-based second-generation matrix metalloproteinase (MMP) inhibitor with potential antineoplastic activity. Rebimastat selectively inhibits several MMPs (MMP 1, 2, 8, 9, and… »
Sorting data into specially chosen classes or bins which differ from those pertaining to the original acquisition. »
A removal or correction of a marketed product that the FDA considers to be in violation of the laws it administers and… »
The date (and time) on which an entity is received. »
A question about whether an individual recieves or received support from their friends. »
Indicates the person or authoritative body who has received something. »
The range between the minimum and maximum cut-off frequencies for a particular receiver, commonly measured in Hertz. »
An electronic device designed to capture an incoming electromagnetic signal and convert it to an audible or visual signal. »
Functions that assign the maximum specificity to each value of sensitivity.The method is used for deciding which clinical data are of importance… »
As part of a cochlear implant, an implanted device designed to receive signal from the external device and then decode the signal… »
A T-lymphocyte that has completed intrathymic development and has exited the thymus. These cells are the youngest peripheral T-lymphocytes and migrate to… »
A substance being studied in the treatment of some types of cancer. Recentin may prevent the growth of new blood vessels that… »
Document type (funding opportunity): a PA or RFA not requiring clearance at the NCI Board of Scientific Advisors »
That part of the axis of a flower stalk that bears the floral organs. »
The body of words that a person recognizes and understands when read or heard. »
A test that assesses an individual's understanding of spoken English language. »
A molecule inside or on the surface of a cell that binds to a specific substance and causes a specific effect in… »
Any intercellular signaling process in which a transmembrane or intracellular receptor in the responding cell binds to a cognate ligand and initiates… »
Receptor Binding involves a temporary non-covalent, typically highly specific and high affinity, interaction through intermolecular physical forces of attraction and spatial complementarity… »
The study of the regulation of gene expression by nuclear receptors. Includes the mechanisms by which receptors are themselves regulated. … »
A multicellular process that regulates the extent of response to a stimulus either by modulation of active receptors or inhibition of intracellular… »
A multicellular process that regulates the number of transmembrane receptors, by means of increased internalization or decreased expression of the transmembrane… »
Receptor Genes encode cell surface or cytoplasmic receptor proteins that each bind to specific signaling factors (such as a hormone, antigen, or… »
A process by which cells internalize molecules or viruses. Receptors on the plasma membrane of the target cell bind to specific cell… »
Agents that dilate blood vessels, loosen tight junctions and selectively deliver entrapped agents into tumor cells by receptor interaction. »
Encoded by Receptor Serine/Threonine Kinase Genes, Receptor Serine/Threonine Kinases bind to specific signaling factors causing a conformational and functional change in the… »
Receptor Serine/Threonine Kinase Genes encode receptor proteins that each bind to specific signaling factors causing a conformational and functional change in the… »
An intercellular process that involves a cellular receptor binding to a cognate ligand and results in a specific cellular response. »
Refers to the presence or absence of specific receptor molecules on the surface of a cells in a specimen. »
A class of membrane receptors that contain protein tyrosine kinase activity. This enzymatic activity is integral to the function of the… »
Tyrosine kinase receptors (TRKs) are a family of genes encoding neurotrophin receptors that include trkA, trkB, and trkC, which are related to… »
A process that negatively regulates the intracellular catalytic activities that originate with the binding of a tyrosine kinase-associated transmembrane receptor with its… »
A pyrazolobenzodiazepine small molecule with potential antiangiogenesis and antineoplastic activities. Mitosis-angiogenesis inhibitor (MAI) R1530 inhibits multiple receptor tyrosine kinases involved in angiogenesis,… »
Receptor tyrosine-protein kinase erbB-2 (1255 aa, ~138 kDa) is encoded by the human ERBB2 gene. This protein is involved in cell proliferation,… »
Receptor tyrosine-protein kinase erbB3 (1342 aa, ~148 kDa) is encoded by the human ERBB3 gene. This protein plays a role in protein… »
Receptor tyrosine-protein kinase erbB-4 (1308 aa, ~147 kDa) is encoded by the human ERBB4 gene. This protein is involved in multicellular organismal… »
A family of transcription factors that are activated by signaling mediated by tumor growth factor-beta (TGF-beta) superfamily ligand-receptor interactions. Once activated, R-SMADs… »
Receptor-interacting serine/threonine-protein kinase 1 (671 aa, ~76 kDa) is encoded by the human RIPK1 gene. This protein plays a role in signaling… »
Receptor-interacting serine/threonine-protein kinase 2 (540 aa, ~61 kDa) is encoded by the human RIPK2 gene. This protein is involved in protein phosphorylation,… »
Receptor-interacting serine/threonine-protein kinase 3 (518 aa, ~57 kDa) is encoded by the human RIPK3 gene. This protein plays a role in the… »
Receptor-interacting serine/threonine-protein kinase 4 (832 aa, ~92 kDa) is encoded by the human RIPK4 gene. This protein plays a role in the… »
A family of genes that encode transmembrane receptors, which also have protein tyrosine phosphatase activity. These genes are involved in both the… »
Receptor-type tyrosine-protein phosphatase C (1304 aa, ~147 kDa) is encoded by the human PTPRC gene. This protein plays a role in protein… »
Receptor-type tyrosine-protein phosphatase delta (1912 aa, ~215 kDa) is encoded by the human PTPRD gene. This protein is involved in both dendrite… »
Receptor-type tyrosine-protein phosphatase epsilon (700 aa, ~81 kDa) is encoded by the human PTPRE gene. This protein plays a role in cytokine… »
Receptor-type tyrosine-protein phosphatase epsilon isoform 2 (642 aa, ~75 kDa) is encoded by the human PTPRE gene. This protein is involved in… »
Receptor-type tyrosine-protein phosphatase eta (1337 aa, ~146 kDa) is encoded by the human PTPRJ gene. This protein plays a role in protein… »
Receptor-type tyrosine-protein phosphatase gamma (1445 aa, ~162 kDa) is encoded by the human PTPRG gene. This protein is involved in both protein… »
Receptor-type tyrosine-protein phosphatase kappa (1439 aa, ~162 kDa) is encoded by the human PTPRK gene. This protein is involved in protein dephosphorylation,… »
Receptor-type tyrosine-protein phosphatase R (657 aa, ~74 kDa) is encoded by the human PTPRR gene. This protein is involved in both protein… »
Receptor-type tyrosine-protein phosphatase T (1441 aa, ~162 kDa) is encoded by the human PTPRT gene. This protein is involved in cell-cell adhesion,… »
Reintroduction of previously withdrawn medical intervention in the same patient. »
In medicine, a person who receives blood, cells, tissue, or an organ from another person, such as in a blood transfusion or… »
Concerning each of two or more things, especially those given or done in return. In mathematics, used to denote different kinds of… »
The SI unit of wave number, the spatial analogue of frequency; closely related to the concept of the wave vector. »
A standard way to measure how well a cancer patient responds to treatment. It is based on whether tumors shrink, stay the… »
The act of seeing something as familiar. »
In genetics, describes DNA, proteins, cells, or organisms that are made by combining genetic material from two different sources. Recombinant substances are… »
A recombinant peptide that is chemically identical to or similar to the endogenous 70-kD heat shock protein (HSP70). HSP70 is a… »
Dimeric growth factors of the TGF family with effects on a range of cell types in addition to promoting FSH release in… »
A replication-defective, recombinant adenoviral vector encoding the wild-type human tumor-suppressor protein p53 gene with potential antineoplastic activity. Upon intratumoral administration, rAD-p53 binds… »
A recombinant replication-defective adenovirus which encodes the gene for the cytokine human interferon-beta (IFN-beta). Once inserted into and replicating in host tumor… »
A replication-deficient recombinant adenovirus encoding human interferon alpha-2b with potential antineoplastic activity. Upon intravesical administration, recombinant adenovirus-interferon SCH 721015 infects nearby tumor… »
A non-replicating recombinant adenovirus type 5 (Ad5)-vector encoding the gene for interferon alpha-2b (IFN alpha-2b) and the gene transfer enhancement agent Syn… »
A replication-defective adenovirus containing a gene that encodes the human protein L523S with potential antineoplastic activity. Upon administration, recombinant adenovirus-L523S vaccine expresses… »
A substance that has been studied in the treatment of some types of cancer. Recombinant adenovirus-p53 is a weakened adenovirus that carries… »
A genetically-engineered adenovirus that contains the gene that encodes the human tumor-suppressor protein p53 with potential antineoplastic activity. Recombinant adenovirus-p53 SCH-58500 delivers… »
One of a number of chemotactic cytokines. Alpha chemokines are small polypeptides released by macrophages, endothelial cells, keratinocytes, fibroblasts, and smooth muscle… »
A recombinant form of amphiregulin, a member of the heparin-binding epidermal growth factor (EGF) family. Endogenous amphiregulin is an autocrine growth factor,… »
A 14kD non-glycosylated human derived angiogenesis factor, which has the ability to induce neovascularisation with a unique ribonucleolytic activity. »
Antibodies produced by recombinant DNA techniques. »
An orally available, genetically engineered Salmonella typhimurium strain expressing a truncated form of the human cytokine interleukin-2 (IL-2) gene, with antitumor… »
A recombinant vaccine containing a genetically detoxified adenylate cyclase toxin (CyaA) of Bordetella pertussis coupled, through its catalytic site, to the melanoma… »
Formulated therapeutic analogs of one of a number of endogenous chemotactic polypeptide cytokines. Beta chemokine is synthesized and released by macrophages,… »
A therapeutic analogue of an endogenous, platelet-specific protein that is a member of the alpha chemokine family. Beta thromboglobulin may be… »
A recombinant form of the endogenous Betacellulin, a member of the Epidermal Growth Factor family that is expressed primarily in the pancreas… »
A recombinant, bispecific, single-chain antibody directed against both the T-cell surface-associated costimulatory molecule CD28 and a melanoma-associated proteoglycan (MAPG) with potential antitumor… »
Recombinant therapeutic agents chemically identical to or similar to endogenous nerve growth factors (neurotrophins) that play vital roles in the development of… »
Smaller fragment formed when C5 convertase splits C5 into C5a and C5b. C5a is a 74-amino acid peptide that includes a carboxy-terminal… »
A recombinant therapeutic agent which is chemically identical to or similar to CD40-ligand. CD40-ligand, also known as CD40L/TRAP and CD154, is a… »
A recombinant sialidase fusion protein composed of a sialidase catalytic domain derived from Actinomyces viscosus, a constituent of the normal oral and… »
Formulated therapeutic analogs of one of a number of endogenous small polypeptide cytokines with potential antineoplastic activity. Synthesized by macrophages, endothelial cells,… »
Glycoprotein growth factors produced by monocytes, macrophages, or activated lymphocytes that stimulate the proliferation of bone marrow cells and differentiation of stem… »
A recombinant peptide hormone chemically identical to or similar to human polypeptide hormone corticotropin (adrenocorticotropic hormone; ACTH). Secreted by the anterior pituitary… »
Connective Tissue-Activating Peptide III is a platelet-derived growth factor that stimulates in fibroblasts mitogenesis, extracellular matrix synthesis, glucose metabolism, and plasminogen activator… »
Recombinant form of endogenous delta-chemokine family. »
A cancer vaccine consisting of a truncated recombinant HER2 peptide (dHER2) with potential antineoplastic activity. Upon administration, recombinant dHER2 vaccine may stimulate… »
A recombinant dimeric fusion peptide of the human granulocyte colony-stimulating factor (G-CSF; filgrastim), with immunomodulating and hematopoietic activities. Recombinant dimeric filgrastim fusion… »
Biologically active DNA which has been formed by the in vitro joining of segments of DNA from different sources usually for the… »
A plasmid DNA encoding human L523S, an RNA-binding protein that belongs to the KOC (K homology domain containing protein overexpressed in cancer)… »
Epithelial neutrophil activating peptide-78. A 78 amino acid member of the CXC family of chemokines, produced and secreted upon stimulation by… »
A recombinant therapeutic agent which is chemically identical to or similar to the endogenous chemokine eotaxin, a member of the C-C cytokine… »
A recombinant fusion protein composed of the full-length extracellular domain (soluble) of human receptor tyrosine kinase ephrin type-B receptor 4 (sEphB4) and… »
A recombinant therapeutic agent which is chemically identical to or similar to endogenous epidermal growth factor (EGF). As a mitogen, EGF… »
A recombinant therapeutic agent which is chemically identical to or similar to the endogenous glycoprotein erythropoietin (Epo). Epo promotes the differentiation… »
A recombinant agent, which is chemically identical to or similar to the endogenous protein Fas ligand, a protein related to tumor necrosis… »
A family of small polypeptide growth factors that share several common features including a strong affinity for HEPARIN, and a central barrel-shaped… »
A recombinant therapeutic agent which is chemically identical to or similar to endogenous fibroblast growth factor 1 (FGF-1. Because of the mitogenic… »
A recombinant therapeutic agent which is chemically identical to or similar to endogenous fibroblast growth factor 2 (FGF-2). Reflecting its endogenous… »
A recombinant agent which is chemically identical to or similar to endogenous fibroblast growth factor 3 (FGF-3). FGF-3 is a growth factor… »
A recombinant therapeutic agent which is chemically identical to or similar to endogenous fibroblast growth factor 4 (FGF-4). Therapeutic FGF-4 induces vascular… »
A recombinant form of the heparin-binding fibroblast growth factor 5 (FGF-5). FGF-5 may function as a growth factor during embryogenesis and… »
A recombinant therapeutic agent which is chemically identical to or similar to endogenous fibroblast growth factor 6 (FGF-6). Because of the… »
A recombinant therapeutic agent which is chemically identical to or similar to endogenous fibroblast growth factor 7 (FGF-7). Because it stimulates proliferation… »
A recombinant therapeutic agent which is chemically identical to or similar to the endogenous cytokine Flt3. Flt3 ligand binds to the Flt3… »
A cancer vaccine adjuvant consisting of a recombinant fowlpox virus encoding human granulocyte-macrophage colony-stimulating factor (GM-CSF). GM-CSF binds to specific cell surface… »
A recombinant fowlpox virus vector encoding human B7.1 (CD80 antigen), a T-cell costimulatory molecule. Recombinant Fowlpox-B7.1 may be used as a… »
A cancer vaccine comprised of a recombinant fowlpox virus vector encoding the stimulatory molecule transgene B7-1. Recombinant fowlpox-B7.1 vaccine may enhance antigen… »
A cancer vaccine made with a form of a chicken virus that does not cause disease in humans. It is being studied… »
A cancer vaccine comprised of a recombinant fowlpox virus vector encoding the carcinoembryonic antigen (CEA) and a TRIad of COstimulatory Molecules (B7-1,… »
A vaccine adjuvant comprised of a recombinant fowlpox virus vector encoding the protein cytokine GM-CSF. GM-CSF is a protein cytokine secreted by… »
A viral vaccine comprised of a recombinant fowlpox vector construct encoding a modified epitope of the melanoma antigen glycoprotein 100 (gp100), ES-2092M(gp100),… »
A vaccine consisting of a replication-defective recombinant fowlpox virus that encodes for the murine melanoma antigen glycoprotein 100 (mgp100) with potential antineoplastic… »
A recombinant cancer vaccine consisting of a fowlpox virus vector encoding the prostate-specific antigen (PSA). This agent stimulates cytotoxic T-lymphocytes to target… »
A cancer vaccine consisting of a recombinant fowlpox virus encoding human prostate-specific antigen (PSA). Administration of this agent may stimulate a cytotoxic… »
A cancer vaccine consisting of a recombinant fowlpox virus encoding fragment of human prostate-specific antigen (PSA), PSA:154-163 (155L), and a TRIad of… »
A cancer vaccine made with a form of a chicken virus that does not cause disease in humans. It is being studied… »
A recombinant fowlpox virus vaccine with potential antineoplastic activity. Binding to the melanoma antigen tyrosinase, recombinant fowlpox-tyrosinase vaccine generates cellular immune responses… »
A pro-inflammatory delta chemokine with potential antineoplastic activity. Fractalkine induces the adhesion and migration of T lymphocytes, monocytes and natural killer… »
A family of synthetic or recombinant C-type chemokines lacking adjacent cysteine residues and act as chemoattractants for lymphocytes. »
A recombinant therapeutic agent which is chemically identical to or similar to endogenous glial cell line-derived neurotrophic factor (GDNF). GDNF is… »
The recombinant form of the endogenous polypeptide hormone Glucagon consisting of 29 amino acids responsible for the release of stored glucose, causing… »
A synthetic luteinizing hormone releasing hormone (LHRH) identical to or similar to the endogenous hormone. Synthesized in and secreted by the hypothalamus,… »
A recombinant therapeutic agent which is chemically identical to or similar to the endogenous cytokine granulocyte colony-stimulating factor (G-CSF). Secreted by… »
A recombinant therapeutic agent which is chemically identical to or similar to the endogenous glycoprotein cytokine growth factor granulocyte-macrophage colony stimulating factor… »
A recombinant peptide chemically identical or similar to the endogenous alpha chemokine GRO1 (MGSA) protein. GRO1 protein belongs to a superfamily of… »
Formulated therapeutic proteins that are either isolated from endogenous sources or manufactured in a laboratory. Growth factors bind to specific receptors… »
A haplotype is the order of gene alleles present on a particular chromosome. Thus, a recombinant haplotype exists when a particular… »
Drugs derived from hematopoietic growth factor that promote the development of blood cells. »
Recombinant forms of endogenous Heparin-binding Neurotrophic factors »
A recombinant therapeutic agent which is chemically identical to or similar to the endogenous glycoprotein cytokine hepatocyte growth factor (HGF), which is… »
A growth factor of the EGF family that induces growth and differentiation of epithelial, glial and muscle cells in culture. It… »
A therapeutic recombinant analogue of a member of the endogenous CC chemokines with potential antineoplastic activity. Expressed by various lymphoid tissues, endogenous… »
A replication selective, recombinant, E1B and partial E3 gene deleted form of human adenovirus type 5, with potential antineoplastic activity. Upon intratumoral… »
A long-acting recombinant fusion protein incorporating human serum albumin (HSA)-derived and human granulocyte colony stimulating factor (G-CSF)-derived moieties with potential granulopoietic… »
A recombinant, soluble glycosylated form of human angiotensin converting enzyme 2 (rhACE2) with antihypertensive and potential antineoplastic activities. Recombinant human angiotensin converting… »
A recombinant human IgG4 monoclonal antibody directed against transforming growth factor-beta (TGFb) with potential antineoplastic activity. Recombinant human anti-TGF-beta monoclonal antibody specifically… »
An immunoconjugate of recombinant CD4 antigen (rCD4) covalently linked to an immunoglobulin G heavy chain with activity against human immunodeficiency virus… »
A recombinant therapeutic agent which is chemically identical to or similar to the endogenous glycoprotein hormone human chorionic gonadotropin (HCG). HCG… »
A peptide vaccine preparation, containing recombinant human epidermal growth factor (rEGF) linked to the Neisseria meningitidis-derived recombinant immunogenic carrier protein P64k (rP64k)… »
A recombinant human proteolytic fragment of the C-terminal end of type XVIII collagen. Endostatin induces microvascular endothelial cell apoptosis and inhibits endothelial… »
An immunocytokine consisting of human pro-inflammatory cytokine tumor necrosis factor alpha (TNFalpha) fused to a human single-chain variable fragment (scFv) directed against… »
A recombinant chaperone-peptide complex-based vaccine composed of a complex between heat shock protein hsp110 and the human melanoma-associated antigen gp100, with potential… »
A human recombinant form of the naturally occurring human enzyme hyaluronidase with potential chemoadjuvant activity. Upon local administration, recombinant human hyaluronidase hydrolyzes… »
A recombinant agent which is chemically identical to or similar to the endogenous cytokine interleukin 4 (IL-4) with potential antineoplastic activity. … »
A drug used to increase the number of blood cells, especially platelets, in some cancer patients receiving chemotherapy. Recombinant human interleukin-11 is… »
A drug used to treat some types of cancer. It is a form of interleukin-2, a cytokine made by leukocytes (white blood… »
The recombinant form of endogenous MIP-1 beta chemokine that chemoattracts both neutrophils and monocytes, stimulates macrophages, and stimulates myelopoietic cell growth. … »
A substance that causes blood stem cells (cells from which other types of cells develop) to change into different types of blood… »
A recombinant agent, chemically identical or similar to the endogenous small inducible cytokine A8 (MCP-2). This agent is a member of the… »
A cancer vaccine containing autologous dendritic cells pulsed with a fusion product of an epitope of human tumor-associated epithelial mucin 1 (MUC1)… »
A vaccine used to prevent cervical cancer caused by human papillomavirus (HPV) types 16 and 18. Recombinant human papillomavirus bivalent vaccine is… »
A vaccine used to prevent anal, cervical, vulvar, and vaginal cancer caused by human papillomavirus (HPV) types 16, 18, 31, 33, 45,… »
A vaccine used to prevent anal, cervical, vulvar, and vaginal cancer caused by human papillomavirus (HPV) types 16 and 18 and genital… »
A fully recombinant form of the human pentraxin 2 (PTX2) protein with potential antifibrotic activity. Upon intravenous administration, recombinant human serum amyloid… »
A therapeutic glycoprotein cytokine chemically identical to or similar to endogenous human stem cell factor with hematopoietic activity. Recombinant human stem cell… »
A humoral factor that controls blood platelet production through stimulation of megakaryocyte populations. Bone marrow megakaryocytes increase in both size and number… »
A recombinant form of human I-309, an inflammatory CXC cytokine secreted by activated T lymphocytes that appears to be an inducer of… »
Recombinant form of endogenous Insulin-like Growth Factor II exhibiting mitogenic activity. »
Recombinant inbred (RI) strains are derived by systematic inbreeding from the cross of two pre-existing progenitor strains. (from JAX Strain Information) … »
Recombinant therapeutic agents chemically identical to or similar to endogenous glycoproteins which inhibit pituitary production of follicle-stimulating hormone (FSH). Inhibin has… »
A recombinant therapeutic agent which is chemically identical to or similar to an endogenous glycoprotein which inhibits pituitary production of follicle-stimulating hormone… »
A recombinant therapeutic agent which is chemically identical to or similar to an endogenous glycoprotein which inhibits pituitary production of follicle-stimulating hormone… »
A recombinant human antiapoptotic growth factor. Recombinant insulin-like growth factor (IGF) binds to and activates the insulin and IGF receptors; activation… »
One of a group of recombinant therapeutic glycoprotein cytokines with antiviral, anti-proliferative, and immunomodulating activities. Interferons bind to specific cell-surface receptors, leading… »
A class of naturally-isolated or recombinant therapeutic peptides used as antiviral and anti-tumor agents. Alpha interferons are cytokines produced by nucleated… »
The non-glycosylated recombinant interferon alpha, subtype 1b, with immunostimulatory and antineoplastic activities. Alpha interferon-1b binds to specific cell-surface receptors, resulting in the… »
A non-glycosylated recombinant human alpha interferon, subtype 2a, produced in the bacterium E. coli. Interferon alpha-2a binds to its specific cell-surface… »
A drug used to treat AIDS-related Kaposi sarcoma in certain patients, hairy cell leukemia, and melanoma that has been removed by… »
A proprietary recombinant protein highly resembling human interferon alpha 2b (IFN-a2b), with potential anti-tumor, anti-inflammatory, immunomodulating and antiviral activities. Upon injection, recombinant… »
A recombinant protein which is chemically identical to or similar to endogenous interferon beta with antiviral and anti-tumor activities. Endogenous interferons beta… »
A recombinant therapeutic agent which is chemically identical to or similar to the endogenous lymphokine interferon gamma (IFN-gamma) with antineoplastic, immunoregulatory, and… »
A recombinant agent, chemically identical or similar to the endogenous small inducible cytokine B10 (IP-10). Interferon-alpha inducible protein 10 is secreted from… »
Formulated therapeutic analogs of one of a number of endogenous cytokine interleukins. Produced by T cells, macrophages, and other cells, interleukins… »
A recombinant cytokine chemically identical to or similar to interleukin-10 (IL-10) secreted by certain leukocytes with immunomodulatory activities. IL-10 is an anti-inflammatory… »
A recombinant therapeutic agent which is chemically identical to or similar to the endogenous cytokine interleukin-1 (IL-1). Produced mainly by monocytes, endogenous… »
Any of the recombinant form of the naturally occurring Interleukin-1 Receptor Antagonist that blocks the biological activity of Interleukin-1 by binding to… »
A recombinant agent which is chemically identical to or similar to the endogenous protein cytokine interleukin-1 (IL-1). The IL-1 precursor is produced… »
A recombinant therapeutic agent which is chemically identical to or similar to the endogenous protein cytokine interleukin 1 (IL-1)-beta. Produced by monocytes… »
A recombinant form of the endogenous heterodimeric cytokine interleukin-12 with potential antineoplastic activity. Recombinant interleukin-12 binds to and activates its cell-surface… »
The recombinant analogue of an endogenous cytokine interleukin 13 with potential antineoplastic activity. Produced by lymphocytes and exhibiting a variety of functions,… »
A recombinant peptide, which is chemically identical or similar to the endogenous cytokine interleukin-14 (IL-14). The cytokine inhibits immunoglobulin secretion and selectively… »
A recombinant agent that is chemically identical or similar to the endogenous cytokine interleukin-15 (IL-15) with immunomodulating activity. IL-15, secreted by mononuclear… »
A recombinant chemokine of human lymphotactin which is produced by activated progenitor T cells and characterized by specific chemotactic activity for… »
A recombinant agent, which is chemically identical or similar to the endogenous cytokine interleukin-17 (IL-17). IL-17 is produced by cytotoxic T cells… »
A recombinant therapeutic agent which is chemically identical to or similar to the endogenous cytokine interleukin-18 (IL-18). Produced primarily by macrophages, IL-18… »
Any recombinant analog of endogenous interleukin-2 (IL-2), a cytokine involved in intercellular communication related to cell differentiation, proliferation, inflammation, hematopoiesis, neuronal functions,… »
A recombinant form of interleukin-3, a cytokine produced by activated T-cells and mast cells involved in intercellular communication, hematopoiesis, and inflammation. IL-3… »
A recombinant therapeutic agent which is chemically identical to or similar to the endogenous cytokine interleukin-5 (IL-5). Produced by T cells,… »
A recombinant therapeutic agent which is chemically identical to or similar to the endogenous cytokine interleukin-6 (IL-6) with antiapoptotic, proinflammatory, antiinflammatory, proproliferative… »
A recombinant protein which is chemically identical to or similar to endogenous interleukin-7 (IL-7) with hematopoietic and immunopotentiating properties. Produced by bone… »
A member of the CXC chemokine family. This chemokine is one of the major mediators of the inflammatory response. This chemokine is… »
A recombinant therapeutic agent which is chemically identical to or similar to the endogenous cytokine interleukin-9 (IL-9). Produced by CD4+ lymphocytes, IL-9… »
A recombinant counterpart of tumor-associated KSA antigen (Ep-CAM), a type-I transmembrane glycoprotein cellular adhesion molecule with a molecular mass of 40 kDa,… »
affects many systems, including hematopoietic, embryonic, bone, hepatic, neuronal, and fat tissues. »
A cocktail preparation of synthetic interleukin (IL) -1, IL-2, IL-6 , tumor necrosis factor (TNF)-alpha, interferon gamma and other cytokines that are… »
A formulated therapeutic analog of the endogenous lymphokine leukoregulin with potential antineoplastic activity. Leukoregulin displays direct and indirect cytotoxicity through tumor… »
A hormone made in the pituitary gland. In females, it acts on the ovaries to make follicles release their eggs and to… »
A type of cytokine produced by lymphocytes for therapeutic use involving cellular immunity. »
A recombinant chemokine of human lymphotactin which is produced by activated progenitor T cells and characterized by specific chemotactic activity for… »
Lymphotoxin is a cytokine that orchestrates lymphoid neogenesis and is present on the surface of activated T-, B-, and LAK cells as… »
A recombinant therapeutic agent which is chemically identical to or similar to the endogenous protein cytokine macrophage colony-stimulating factor (M-CSF). Synthesized endogenously… »
A recombinant therapeutic agent which is chemically identical to or similar to endogenous macrophage inflammatory protein-1, a member of the CC chemokine… »
A therapeutic analogue of the endogenous CXC cytokine macrophage inflammatory protein-2 alpha. Macrophage inflammatory protein-2 alpha attracts and activates neutrophils and may… »
A formulated therapeutic analog of the endogenous pro-inflammatory alpha (CXC) chemokine macrophage inflammatory protein-2 beta that stimulates neutrophil chemotaxis and induces neutrophil… »
A recombinant tumor-specific melanoma antigen. Vaccination with recombinant MAGE-3.1 antigen may induce a host immune response against MAGE-expressing cells, resulting in antitumoral… »
A recombinant form of neurotrophic growth factor that regulates the development and maintenance of motor neurons expressing trk B receptor tyrosine kinase,… »
A recombinant form of a human macrophage inflammatory protein-1 alpha (MIP1-alpha) with a substitution of aspartate to alanine at position 26, with… »
A cancer vaccine comprised of a recombinant modified vaccinia Ankara (MVA) viral vector encoding the 5T4 fetal oncoprotein (MVA-h5T4). Vaccination with recombinant… »
A recombinant therapeutic agent which is chemically identical to or similar to endogenous human monocyte chemoattractant protein-1, a member of the CC… »
An 85-amino acid recombinant peptide derived from protein c2 of the hemophagocytic hookworm Ancylostoma caninum (a common canine parasite) with anticoagulant… »
NERVE GROWTH FACTOR is the first of a series of neurotrophic factors that were found to influence the growth and differentiation of… »
Recombinant forms of endogenous neuropoietic cytokines. »
Recombinant form of endogenous neurotrophic factors, a family of polypeptide growth factors produced by peripheral target tissues as well as the nervous… »
family of polypeptide growth factors produced by peripheral target tissues as well as the nervous system, which are critical to neuronal growth,… »
A genetically engineered synthetic protein, Recombinant NY-ESO-1 Protein (Cancer-Testis Tumor Antigen Family) elicits strong humoral and cellular immune responses to NY-ESO-1-expressing cancers… »
A recombinant, live attenuated, nonpathogenic oncolytic virus containing the oral poliovirus Sabin type 1 in which the internal ribosomal entry site (IRES)… »
A recombinant 26.0 kDa protein, containing 227 amino acid residues, a member of the cytokine family and growth and differentiation factor that… »
A recombinant agent, which is chemically identical to or similar to the endogenous protein Fas ligand OX40, a member of the tumor… »
A synthetic cyclic peptide form of the naturally occurring posterior pituitary hormone oxytocin. Oxytocin binds to oxytocin receptors in the uterine myometrium,… »
A recombinant therapeutic agent that is identical or similar to an 84-amino-acid polypeptide produced by the parathyroid gland which functions to maintain… »
calcium-regulating hormone with endocrine, paracrine, and autocrine actions in bone; can cause hypercalcemia. »
A recombinant form of the endogenous chemokine platelet factor 4 with potential antiangiogenesis and antineoplastic activities. As a heparin-binding tetramer, recombinant platelet… »
Expressed in platelets, human Platelet-Derived Growth Factor (PDGF/VEGF Family) is a mitogenic factor for mesenchymal cells characterized by a motif of eight… »
A recombinant form of the heparin-binding cytokine pleiotrophin. Developmentally regulated, pleiotrophin functions as a growth factor during embryogenesis and the neonatal… »
A recombinant form of the human PRAME (Preferentially Expressed Antigen of Melanoma) protein combined with the AS15 adjuvant, with potential immunostimulatory and… »
Proteins produced by genes or recombinant DNA that has been artificially engineered and inserted into a heterologous host. Recombinant proteins are used… »
In vivo synthesis of recombinant proteins through recombinant DNA techniques, followed by purification. »
A recombinant form of the endogenous polypeptide hormone that exerts immunomodulatory effects primarily on mononuclear cells. Prothymosin alpha stimulates the production… »
A member of the IL-8 superfamily of cytokines and released from platelets and activated T-cells, RANTES is a selective chemoattractant for eosinophils,… »
A whole, heat-killed, recombinant Saccharomyces cerevisiae yeast-based vaccine genetically altered to express the carcinoembryonic antigen (CEA) peptide 610D with potential immunostimulating and… »
A recombinant human soluble CD4 with antiviral activity. Recombinant human soluble CD4 has the amino terminus but not the T-cell binding domain… »
A recombinant form of CD4 antigen with anti-HIV application. Recombinant soluble T4 antigen (rsT4) is derived from cell surface antigen CD4 lacking… »
A recombinant peptide chemically identical or similar to endogenous somatostatin. Somatostatin is a cyclic tetradecapeptide regulating many endocrine and nervous system… »
Recombinant form of endogenous thymopoietin, a thymic hormone. »
A recombinant form of a polypeptide chemically identical to or similar to the hormone secreted by the thymus gland. Thymosin is generally… »
A recombinant form of thyroglobulin identical to or similar to the endogenous iodine-containing glycoprotein. Thyroglobulin is synthesized in the thyroid follicular cell,… »
A peptide hormone secreted by the anterior pituitary. It promotes the growth of the thyroid gland and stimulates the synthesis of thyroid… »
A recombinant form of the human anterior pituitary glycoprotein thyroid stimulating hormone (TSH) with use in the diagnostic setting. With an amino… »
A form of tissue plasminogen activator that is made in the laboratory. It helps dissolve blood clots and is used to treat… »
A recombinant therapeutic agent which is chemically identical to or similar to endogenous transforming growth factor (TGF). Representing peptides of two… »
A recombinant form of Transforming Growth Factor-Alpha, a polypeptide growth factor involved with the growth and differentiation of epidermal and epithelial cells,… »
A recombinant therapeutic agent which is chemically identical to or similar to the endogenous cytokine transforming growth factor-beta (TGF-beta) with proapoptotic and… »
A recombinant form of the endogenous Transforming Growth Factor-Beta 1, a protein involved with the regulation of cell proliferation and differentiation. … »
A recombinant agent, which is chemically identical to or similar to the endogenous cytokine transforming growth factor-beta-3 (TGF-beta-3). TGF-beta-3 modulates cell growth… »
A recombinant polypeptide chemically identical to or similar to the endogenous cytokine transforming growth factor-beta-2 (TGF-beta-2). TGF-beta-2 modulates cell growth and immune… »
A recombinant therapeutic agent which is chemically identical to or similar to one of a number of endogenous tumor necrosis factor (TNF)… »
A recombinant therapeutic agent which is chemically identical to or similar to the endogenous cytokine tumor necrosis factor-alpha with antineoplastic properties. … »
A recombinant agent, which is chemically identical to or similar to the endogenous cytokine tumor necrosis factor-beta (TNF-beta). Produced predominantly by T-lymphocytes… »
A recombinant peptide of the tyrosinase-related protein 1 (TRP1) used in vaccine therapy. Expressed by cells of melanocyte origin, TRP1 is an… »
A recombinant therapeutic agent which is chemically identical to or similar to an endogenous non-mutated melanocyte differentiation antigen expressed by both normal… »
A drug used to treat high blood levels of uric acid in patients with leukemia, lymphoma, and other types of cancer who… »
A vaccinia virus based vaccine expressing human tumor associated epithelial mucin (DF3 antigen; MUC1). MUC1 antigen, a membrane bound glycoprotein expressed by… »
A vaccine consisting of recombinant vaccinia virus encoding prostate specific antigen (PSA). Vaccination with recombinant vaccinia prostate-specific antigen vaccine stimulates the host… »
A vaccine consisting of recombinant modified vaccinia Ankara (MVA) viral vector encoding mutated forms of the genes for the viral oncoproteins E6… »
A recombinant vaccinia virus encoding the T-cell co-stimulatory molecule B7-1. Co-administration of recombinant vaccinia-B7.1 and a tumor-associated antigen in a cancer vaccine… »
A recombinant vaccinia virus encoding the T-cell co-stimulatory molecule B7-1. Co-administration of recombinant vaccinia-B7.1 and a tumor-associated antigen vaccine may enhance tumor-associated… »
A recombinant vaccinia virus encoding carcinoembryonic antigen (CEA). CEA is overexpressed in several cancer cell types, including gastrointestinal, breast, and non-small cell… »
A cancer vaccine made with a form of vaccinia virus that does not cause disease in humans. It is being studied in… »
A vaccine consisting of recombinant vaccinia virus encoding the tumor-associated antigen carcinoembryonic antigen (CEA) and a TRIad of COstimulatory Molecules (B7-1, ICAM-1,… »
A recombinant vaccinia virus that encodes granulocyte-macrophage colony stimulating factor (GM-CSF). By activating T-cells and macrophages, vaccination with recombinant vaccinia GM-CSF… »
A recombinant vaccinia virus encoding a modified peptide of the gp100 melanoma-melanocyte antigen with potential use in cancer immunotherapy. gp100 human… »
A recombinant vaccinia virus encoding a modified peptide of the gp100 melanoma-melanocyte antigen with potential use in cancer immunotherapy. gp100 human… »
A vaccine containing a recombinant vaccinia virus that encodes the gene for human mucin-1, a tumor-associated antigen. Upon administration, recombinant vaccinia-MUC-1 vaccine… »
An admixture of recombinant vaccinia virus encoding MUC-1 and recombinant vaccinia virus encoding the murine T-cell co-stimulatory molecule B7.1. MUC-1 is… »
A cancer vaccine consisting of an inactivated recombinant vaccinia virus encoding epitope peptides derived from melanoma-related HLA-A2-restricted tumor-associated antigens (TAAs), including Melan-A(27-35),… »
A cancer vaccine consisting of a recombinant vaccinia viral vector encoding an immunogenic peptide derived from the cancer-testis antigen NY-ESO-1, an antigen… »
A recombinant vaccinia virus encoding prostate-specific antigen (PSA). Vaccination with recombinant vaccinia-PSA may stimulate the host immune system to mount a… »
A recombinant vaccinia virus encoding a modified peptide of the prostate-specific antigen (PSA) with a leucine substitution at position 155, and a… »
A recombinant vaccinia virus encoding prostate-specific antigen (PSA) and prostate-specific membrane antigen (PSMA) with potential use in cancer immunotherapy. »
A cancer vaccine made with a form of a vaccinia virus that does not cause disease in humans. It is being studied… »
A recombinant vaccinia virus encoding the melanocyte differentiation antigen tyrosinase-related protein-1 (TRP-1) with potential use in cancer immunotherapy. »
A recombinant vaccinia virus (based on the modified vaccinia virus Ankara) expressing tyrosinase. Tyrosinase is a melanoma-specific differentiation agent that catalyzes the… »
A recombinant therapeutic agent which is chemically identical to or similar to endogenous vascular endothelial growth factor (VEGF). Produced by a… »
A recombinant, replicating oncolytic vesicular stomatitis virus (VSV) carrying the human interferon-beta (IFN-b) gene, with potential immunomodulating and antineoplastic activities. Upon intratumoral… »
A vaccine produced from genetically engineered viral vector by introduction of foreign genetic materials to activate immune response in a host. … »
An individual cell or organisms which carries recombinant DNA »
The percentage of individuals in a population with a non-parental genotype. »
Homologous recombination can operate at both double-strand breaks and free ends. The homologous chromosome serves as a template for DNA repair during… »
Advice telling someone what the best thing to do is. »
The recommended atmospheric pressure for handling or operating a device. »
The recommended humidity level for handling or operating a device. »
The recommended temperature of the environment when handling or operating a device. »
The recommended storage atmospheric pressure for a device. »
The recommended storage humidity level for a device. »
The recommended storage temperature for a device. »
A substance that requires reconstitution with a suitable solvent and is intended for oral administration in a drop-wise fashion. »
A solution that requires reconstitution with a suitable solvent, and is intended for oral administration. »
A classification of the reconstruction filter used to suppress noise, enhance edges, perform resolution recovery and smooth an image. »
The type of mathematical process used to produce the displayed image from the raw k-space data obtained from the receiver circuitry. … »
A doctor who can surgically reshape or rebuild (reconstruct) a part of the body, such as a woman's breast after surgery for… »
Surgery that is done to reshape or rebuild (reconstruct) a part of the body changed by previous surgery. »
Anything (e.g., a document) providing permanent evidence of or information about past events. »
A study in which data from different sources are "linked". Usually used to compile epidemiological data. The logic of record… »
A device designed to capture and store audiovisual or other data. »
One of the possible results of an adverse event outcome that indicates that the event has improved or recuperated. »
One of the possible results of an adverse event outcome where the subject recuperated but retained pathological conditions resulting from the prior… »
One of the possible results of an adverse event outcome where the subject recuperated and is free of any pathological conditions resulting… »
One of the possible results of an adverse event outcome that indicates that the event is improving. »
A healing process and/or an outcome implying relative health. The term is typically used in the context of direct and indirect… »
A process that derives plasma from single units of whole blood or as a by-product from the preparation of blood components from… »
A method whereby a subject is allowed to recover for a specific period of time after an activity before it is… »
The duration from the end of dosing to the final sacrifice of the subject. »
RecQ family proteins are 3'-5' DNA helicases. All RecQ family proteins include a domain of approx. 450 amino acids that contains… »
RecQ-mediated genome instability protein 2 (147 aa, ~16 kDa) is encoded by the human C16orf75 gene. This protein is involved in the… »
This gene is involved in DNA unwinding and the promotion of DNA strand annealing. »
Human RECQL wild-type allele is located within 12p12 and is approximately 32 kb in length. This allele, which encodes ATP-dependent DNA helicase… »
This gene is involved in the initiation of DNA replication and sister-chromatid cohesion. »
Human RECQL4 wild-type allele is located in the vicinity of 8q24.3 and is approximately 6 kb in length. This allele, which encodes… »
This gene plays a role in the regulation of DNA topology. »
Human RECQL5 wild-type allele is located within 17q25.2-q25.3 and is approximately 40 kb in length. This allele, which encodes ATP-dependent DNA helicase… »
Any activity that is intended for refreshment or diversion. »
A drug used for personal enjoyment rather than for medicinal purposes. »
A type of therapy that uses activities to help meet the physical and emotional needs of patients with an illness or disability… »
The process of enrolling, enlisting, or adding individuals to a group. »
By or having to do with the rectum. The rectum is the last several inches of the large intestine closest to the… »
An adenocarcinoma arising from the rectum. It is more frequently seen in populations with a Western type diet and in patients… »
An adenoma that arises from the rectum. The group of rectal adenomas includes tubular, villous, and tubulovillous adenomas, traditional serrated adenomas,… »
An adenoma that arises from the rectum. It is characterized by the presence of severe epithelial dysplasia. »
A polypoid adenoma that arises from and protrudes into the lumen of the rectum. Epithelial dysplasia is always present. According… »
An unusual rectal carcinoma characterized by the presence of glandular and squamous carcinomatous components. The two carcinomatous components may be admixed… »
Leakage due to breakdown of a rectal anastomosis. »
An air filled rectal balloon that is used for prostate immobilization in patients receiving radiation therapy for prostate cancer. »
Removal of rectal tissue, for microscopic examination. »
Cancer that forms in the tissues of the rectum (the last several inches of the large intestine closest to the anus). … »
A malignant epithelial neoplasm that arises from the rectum and invades through the muscularis mucosa into the submucosa. The vast majority… »
A term that refers to the staging of rectal carcinoma according to the American Joint Committee on Cancer, 7th edition. »
A cream intended for administration in or around the rectum. »
A rare, invasive rectal adenocarcinoma characterized by the presence of malignant cribriform glands with central necrotic changes. »
The rectum is the lower part of your large intestine where your body stores stool. Problems with rectum are common. They include… »
A substance intended for administration in or around the rectum. »
A morphologic finding indicating the presence of dysplastic glandular epithelial cells in the rectal mucosa. There is no evidence of… »
An abnormal communication between the rectum and another organ or cavity. »
A foam intended for administration to the rectum. »
A gel intended for administration to the rectum. »
Bleeding originating from the rectal wall and discharged from the anus. »
A serrated polypoid lesion that arises in the rectum. It rarely produces symptoms. This group includes goblet cell rich, mucin… »
A non-neoplastic hamartomatous polyp that arises from the rectum. It is characterized by the presence of tortuous and cystically dilated glands,… »
A Kaposi sarcoma arising from the rectum. »
A well-circumscribed benign smooth muscle neoplasm arising from the rectum. It is characterized by the presence of spindle cells with cigar-shaped nuclei,… »
An aggressive malignant smooth muscle neoplasm that arises from the rectum. It is characterized by a proliferation of neoplastic spindle… »
A benign adipose tissue neoplasm of the rectum. »
An extranodal lymphoma that arises from the rectum. The majority are B-cell non-Hodgkin lymphomas. »
A rare, invasive rectal adenocarcinoma characterized by the presence of sheets of malignant epithelial cells with vesicular nuclei, prominent nucleoli, and abundant… »
An aggressive malignant melanocytic neoplasm that arises from the rectum. »
A rare, invasive rectal adenocarcinoma characterized by the presence of clusters of malignant glandular cells within stromal spaces. »
An invasive adenocarcinoma of the rectum characterized by the presence of pools of extracellular mucin. Malignant glandular epithelial cells are present… »
An inflammatory process affecting the mucous membrane of the rectum. »
A necrotic process involving the rectal wall. »
A benign or malignant neoplasm that affects the rectum. Representative examples of benign neoplasms include lipoma and leiomyoma. Representative examples… »
A neoplasm with neuroendocrine differentiation that arises from the rectum. It includes well differentiated neuroendocrine tumors (low and intermediate grade) and… »
A well differentiated, low grade neuroendocrine tumor (carcinoid tumor) that arises from the rectum. The mitotic count is less than 2 per… »
Blockage of the normal flow of the intestinal contents in the rectum. »
An ointment intended for administration in or around the rectum. »
Pain in the rectal area. »
An rupture in the rectal wall due to traumatic or pathologic processes. »
A polypoid lesion that arises from the rectum and protrudes into the lumen. This group includes adenomatous polyps, serrated polyps, and hamartomatous… »
A powder intended for administration to the rectum. »
Protrusion of the rectal mucous membrane through the anus. There are various degrees: incomplete with no displacement of the anal sphincter muscle;… »
Surgery to rebuild the rectum (the last several inches of the large intestine before the anus) using a section of the… »
A malignant mesenchymal tumor with skeletal muscle differentiation affecting the rectum. »
The introduction of a substance into the gastrointestinal tract by the way of the rectum, usually for systemic action. Depending on the… »
A malignant mesenchymal neoplasm that arises from the rectum. Representative examples include angiosarcoma, Kaposi sarcoma, and leiomyosarcoma. »
A biphasic rectal carcinoma with a spindle cell, sarcomatoid component. »
A rare, invasive rectal adenocarcinoma characterized by the presence of a malignant infiltrate with serrated glandular architecture. »
A polyp that arises from the rectum. It is characterized by the presence of serrated glands and the absence of generalized… »
An infiltrating adenocarcinoma arising from the rectum. It is characterized by the presence of malignant glandular cells with prominent intracytoplasmic… »
An aggressive, high-grade, and poorly differentiated carcinoma with neuroendocrine differentiation that arises from the rectum. It is characterized by the presence… »
A spray intended for administration to the rectum. »
A very rare rectal carcinoma characterized by the presence of a malignant squamous cell infiltrate. »
Narrowing of the rectal lumen. »
A suppository intended for administration within the rectum. »
An adenoma that arises from the rectum. It is characterized by prominent serration of the glands and the presence of generalized… »
A usually polypoid neoplasm that arises from the glandular epithelium of the rectal mucosa. It is characterized by a tubular architectural… »
A neoplasm that arises from the glandular epithelium of the rectal mucosa. It is characterized by tubular and villous architectural patterns. The… »
A circumscribed inflammatory and necrotic erosive lesion in the mucosa surface of the rectum. »
An invasive malignant epithelial tumor that arises from the rectum. There is no morphologic, immunophenotypic, or molecular biological evidence of glandular… »
A neoplasm that arises from the glandular epithelium of the rectal mucosa. It is characterized by a villous architectural pattern. The neoplastic… »
A parallelogram with four right angles. A square is a special rectangle with four equal sides. »
An electrical device designed to convert alternating current to direct current. »
A very simplified scan, now of historical interest, in which a radiation detector is systematically positioned over the subject, viewing only a… »
Inflammation of the mucous membrane that lines the rectum (the last several inches of the large intestine closest to the anus). Also… »
An abnormal communication between the rectum, bladder, and vagina. »
An adenocarcinoma arising from the rectosigmoid area. It is more frequently seen in populations with a Western type diet and in… »
A malignant epithelial neoplasm that arises from the rectosigmoid area and invades through the muscularis mucosa into the submucosa. The vast… »
A term that refers to the staging of rectosigmoid carcinoma according to the American Joint Committee on Cancer, 7th edition. »
A portion of the large intestine that includes the descending colon, sigmoid colon and rectum. »
An invasive adenocarcinoma of the rectosigmoid area characterized by the presence of pools of extracellular mucin. Malignant glandular epithelial cells are… »
A benign or malignant neoplasm that affects the rectosigmoid region. Representative examples of benign neoplasms include lipoma and leiomyoma. Representative… »
The area where the sigmoid colon joins the rectum. »
An infiltrating adenocarcinoma arising from the rectosigmoid area. It is characterized by the presence of malignant glandular cells with prominent intracytoplasmic… »
Surgical removal part or all of the sigmoid colon, and part or all of the rectum. »
A tissue sample that contains the rectum and anus. »
One of the four quadriceps muscles, located in the middle of the front of the thigh. Its actions involve the extension of… »
Cancer that has recurred (come back), usually after a period of time during which the cancer could not be detected. The cancer… »
Specifies whether this is a reappearance of an entity, event or activity. »
In genetics, the likelihood that a hereditary trait or disorder present in one family member will occur again in other family… »
The reemergence of adenosquamous lung carcinoma after a period of remission. »
The reemergence of adrenal cortex carcinoma after a period of remission. »
The reemergence of a pheochromocytoma following surgical removal. »
The reemergence of acute lymphoblastic leukemia in adults after a period of remission. »
The reemergence of acute myeloid leukemia in adults after a period of remission. »
The reemergence of adult Burkitt lymphoma after a period of remission. »
The reemergence of adult diffuse large cell lymphoma after a period of remission. »
The reemergence of adult diffuse mixed cell lymphoma after a period of remission. »
The reemergence of adult diffuse small cleaved cell lymphoma after a period of remission. »
A hepatocellular carcinoma that occurs during adulthood and has recurred after a period of remission. »
The reemergence of Hodgkin lymphoma in adulthood after a period of remission. »
The reemergence of adult immunoblastic lymphoma after a period of remission. »
A hepatocellular carcinoma or intrahepatic cholangiocarcinoma that occurs during adulthood and has recurred after a period of remission. »
The reemergence of adult lymphoblastic lymphoma after a period of remission. »
The re-emergence of non-Hodgkin lymphoma in adults after a period of remission. »
The reemergence of a spinal cord neoplasm in adulthood after a period of remission. »
The reemergence of adult T-cell leukemia/lymphoma after a period of remission »
The reemergence of an aggressive adult non-Hodgkin lymphoma after a period of remission. »
The reemergence of anal canal carcinoma in HIV-positive patients after a period of remission. »
The reemergence of alveolar soft part sarcoma after a period of remission. »
The reemergence of anal carcinoma after a period of remission. »
The reemergence of anaplastic large cell lymphoma after a period of remission. »
The reemergence of angioimmunoblastic T-cell lymphoma after a period of remission »
The reemergence of angiosarcoma after a period of remission. »
The re-emergence of a pituitary gland neoplasm after a period of remission. »
An artery arising from the distal A1 or proximal A1 segment of the anterior cerebral artery that supplies the anteromedial caudate… »
The reemergence of Askin tumor after a period of remission. »
The reemergence of B-cell non-Hodgkin lymphoma after a period of remission. »
A recurrence of adenocarcinoma of the bladder after a period of remission. »
The reemergence of bladder carcinoma after a period of remission »
The reemergence of bladder squamous cell carcinoma after a period of remission »
The reemergence of Ewing sarcoma of the bone after a period of remission. »
The reemergence of a brain neoplasm after a period of remission. »
The reemergence of carcinoma in the breast after a period of remission »
The reemergence of Burkitt lymphoma after a period of remission. »
Cancer that has recurred (come back), usually after a period of time during which the cancer could not be detected. The cancer… »
TNM staging performed for recurrent cancer. »
The reemergence of a central nervous system neoplasm after a period of remission. »
The reemergence of cervical carcinoma after a period of remission. »
The reemergence of acute lymphoblastic leukemia in childhood after a period of remission. »
The reemergence of acute myeloid leukemia in childhood after a period of remission. »
The reemergence of Burkitt lymphoma in childhood after a period of remission. »
Regrowth of benign and malignant childhood cerebellar astrocytomas that have previously been subjected to surgical resection and less frequently other forms of… »
A hepatocellular carcinoma that occurs during childhood and has recurred after a period of remission. »
The reemergence of Hodgkin lymphoma after a period of remission during childhood. »
The reemergence of childhood large cell lymphoma after a period of remission. »
A hepatocellular carcinoma or hepatoblastoma that occurs during childhood and has recurred after a period of remission. »
The reemergence of lymphoblastic lymphoma in childhood after a period of remission. »
The reemergence of a malignant germ cell tumor in children after a period of remission. »
The reemergence of childhood medulloblastoma after a period of remission. »
The reemergence of childhood rhabdomyosarcoma after a period of remission. »
The reemergence of a spinal cord neoplasm in childhood after a period of remission. »
A cholangiocarcinoma that has recurred after a period of remission. »
The reemergence of chondrosarcoma after a period of remission. »
The reemergence of chronic lymphocytic leukemia after a period of remission. »
The reemergence of chronic myelogenous leukemia after a period of remission. »
The reemergence of colon carcinoma after a period of remission. »
The reemergence of colorectal carcinoma after a period of remission. »
The reemergence of diffuse large B-cell lymphoma after a period of remission. »
The return of a disease after a period of remission. »
Recurrence of symptoms of a disease, at a site different and away from the original site. »
Recurrence of symptoms of a disease at the original site. »
The reemergence of duodenal carcinoma after a period of remission. »
The reemergence of epithelioid sarcoma after a period of remission »
An esophageal adenocarcinoma which has reappeared after a period of remission or after presumed treatment. »
An esophageal carcinoma which has reappeared after a period of remission or after presumed treatment. »
An esophageal squamous cell carcinoma which has reappeared after a period of remission or after presumed treatment. »
Ewing sarcoma which has recurred after treatment and/or remission. While initial complete responses are not uncommon, there is a fair chance of… »
The reemergence of a small round cell tumor with or without neural differentiation after a period of remission. »
The reemergence of an extrahepatic bile duct carcinoma after a period of remission. »
Reemergence of extra-osseous Ewing sarcoma after a period of remission. »
Reemergence of extraskeletal myxoid chondrosarcoma after a period of remission »
The reemergence of extraskeletal osteosarcoma after a period of remission. »
The reemergence of female reproductive system carcinoma after a period of remission. »
Fetal heart rate decelerations that occur with greater than or equal to 50 percent of uterine contractions within a 20 minute… »
The reemergence of gallbladder carcinoma after a period of remission. »
The reemergence of gastric carcinoma after a period of remission. »
The reemergence of carcinoma in any part of the gastrointestinal system after a period of remission. »
A well differentiated neuroendocrine tumor (carcinoid tumor) that arises from the gastrointestinal system and has reemerged after a period of remission. … »
A laboratory test result indicating the presence of recurrent genetic abnormalities in cells. »
The reemergence of gestational trophoblastic tumor after a period of remission. »
The reemergence of grade 1 follicular lymphoma after a period of remission. »
The reemergence of grade 2 follicular lymphoma after a period of remission. »
The reemergence of grade 3 follicular lymphoma after a period of remission. »
The reemergence of carcinoma in the head and neck region after a period of remission. »
The reemergence of hepatoblastoma after a period of remission. »
The reemergence of hepatocellular carcinoma after a period of remission »
The reemergence of high grade B-cell lymphoma Burkitt-like lymphoma after a period of remission »
The reemergence of Hodgkin lymphoma after a period of remission. »
The reemergence of hypopharyngeal carcinoma after a period of remission. »
Reemergence of squamous cell carcinoma of the hypopharynx after a period of remission. »
The reemergence of inflammatory carcinoma of the breast after a period of remission »
Reappearance of cholestasis caused by obstruction within the liver. »
The reemergence of Kaposi sarcoma after a period of remission. »
The re-emergence of large cell lung carcinoma after a period of remission. »
The reemergence of laryngeal carcinoma after a period of remission. »
Damage to the recurrent laryngeal nerve. »
Paralysis of the recurrent laryngeal nerve. Causes include surgical and non-surgical traumas, neoplasms (e.g., lung carcinoma), and inflammatory neuritis. »
The reemergence of squamous cell carcinoma of the larynx after a period of remission. »
The reemergence of verrucous carcinoma of the larynx after a period of remission. »
The reemergence of leiomyosarcoma after a period of remission »
The reemergence of lentigo maligna after a period of remission »
The reemergence of lip and/or oral cavity carcinoma after a period of remission. »
Reemergence of basal cell carcinoma of the lip after a period of remission. »
The reemergence of a malignant adipose tissue neoplasm after a period of remission. »
The reemergence of liver carcinoma after a period of remission. »
The re-emergence of lung adenocarcinoma after a period of remission. »
Lung carcinoma that has re-emerged after a period of remission. »
The reemergence of lymphoplasmacytic lymphoma after a period of remission. »
The reemergence of a carcinoma that affects the male reproductive system after a period of remission. »
The reemergence of a malignant duodenal neoplasm after a period of remission. »
The reemergence of a malignant neoplasm of the endocervix after a period of remission. »
The reemergence of a malignant neoplasm of the stomach after a period of remission. »
A rare malignant mesenchymal neoplasm, believed to have its origin in smooth muscle derived pericytes, which has recurred after treatment. »
The reemergence of a hypopharyngeal malignant neoplasm after a period of remission. »
The reemergence of malignant mesothelioma after a period of remission »
The reemergence of a nasopharyngeal malignant neoplasm after a period of remission. »
The reemergence of a malignant neoplasm after a period of remission. »
The reemergence of a malignant salivary gland neoplasm after a period of remission. »
The reemergence of a lip or oral cavity malignant neoplasm after a period of remission. »
A malignant tumor of neural sheath origin-lesions reappearing after an intermission or remission. »
Malignant testicular germ cell tumor reemerging after a period of remission. »
Reemergence of malignant thymoma after a period of remission. »
The reemergence of a mantle cell lymphoma after a period of remission. »
The reemergence of marginal zone B-cell lymphoma after a period of remission. »
The reemergence of medulloblastoma after a period of remission. »
The reemergence of a meningioma after a period of remission. »
The reemergence of metastatic squamous cell carcinoma of unknown primary in the neck region after a period of remission. »
The reemergence of nasal cavity or paranasal sinus carcinoma after a period of remission. »
The reemergence of nasal type NK/T-cell lymphoma after a period of remission. »
The reemergence of keratinizing squamous cell carcinoma of the nasopharynx after a period of remission. »
The reemergence of undifferentiated carcinoma of the nasopharynx after a period of remission. »
The reemergence of nasopharyngeal carcinoma after a period of remission. »
The reemergence of a neoplasm after a period of remission »
The reemergence of neuroblastoma after a period of remission. »
The reemergence of non-Hodgkin lymphoma after a period of remission. »
The re-emergence of non-small cell lung carcinoma after a period of remission. »
The reemergence of adenoid cystic carcinoma in the oral cavity after a period of remission. »
The reemergence of carcinoma in the oral cavity after a period of remission. »
The reemergence of mucoepidermoid carcinoma in the oral cavity after a period of remission. »
Reemergence of squamous cell carcinoma of the oral cavity after a period of remission. »
Reemergence of verrucous carcinoma of the oral cavity after a period of remission. »
The reemergence of oropharyngeal carcinoma after a period of remission. »
Reemergence of squamous cell carcinoma of the oropharynx after a period of remission. »
The reemergence of osteosarcoma after a period of remission. »
The reemergence of ovarian carcinoma after a period of remission. »
The re-emergence of ovarian germ cell tumor after a period of remission. »
The reemergence of pancreatic carcinoma after a period of remission. »
The reemergence of parathyroid gland carcinoma after a period of remission. »
A carcinoma of the penis that reappears after a period of remission. »
The reemergence of a small round cell tumor with neural differentiation after a period of remission. »
The reemergence of peripheral primitive neuroectodermal tumor of bone after a period of remission. »
The reemergence of malignant peritoneal mesothelioma after a period of remission »
The reemergence of carcinoma of the pharynx after a period of remission. »
The reemergence of plasma cell myeloma after a period of remission. »
The reemergence of pleural malignant mesothelioma after a period of remission. »
The reemergence of a primitive neuroectodermal tumor of the central or the peripheral nervous system after a period of remission. »
Prostate carcinoma reemerging after a period of remission. »
The reemergence of rectal carcinoma after a period of remission. »
The reemergence of rectosigmoid carcinoma after a period of remission. »
A reemergence of renal cell carcinoma after a period of remission. »
The reemergence of Wilms tumor of the kidney after a period of remission. »
The reemergence of rhabdomyosarcoma after a period of remission. »
The reemergence of salivary gland carcinoma after a period of remission. »
The reemergence of small cell carcinoma of the lung after a period of remission. »
The reemergence of small intestine carcinoma after a period of remission. »
The reemergence of B-cell small lymphocytic lymphoma after a period of remission »
The reemergence of a spinal cord neoplasm after a period of remission. »
The re-emergence of squamous cell lung carcinoma after a period of remission. »
The reemergence of synovial sarcoma after a period of remission »
The reemergence of T-cell non-Hodgkin lymphoma after a period of remission. »
The reemergence of a thyroid gland carcinoma after a period of remission. »
Reemergence of "malignant fibrous histiocytoma" after a period of remission. »
The reemergence of ureter carcinoma after a period of remission »
The reemergence of urethral carcinoma after a period of remission »
Reemergence of transitional cell cancer of the renal pelvis and ureter after a period of remission. »
Reemerging uterine corpus carcinoma after a period of remission. »
The reemergence of uterine corpus sarcoma after a period of remission. »
The reemergence of vaginal carcinoma after a period of remission. »
Variable decelerations that occur with greater than or equal to 50 percent of uterine contractions. They are usually associated with umbilical cord… »
The reemergence of vulvar carcinoma after a period of remission. »
An adverse event that occurs and resolves during a cycle or course of medical intervention and then reoccurs in a later cycle… »
A set of pretreatment prognostic factors used to predict potential outcomes for neurooncology patients. »
The hue of the long-wave end of the visible spectrum, evoked in the human observer by radiant energy with wavelengths of approximately… »
A type of blood cell that is made in the bone marrow and found in the blood. Red blood cells contain a… »
The determination of the amount of red blood cell casts present in a urine sample. »
Any procedure used to process or manipulate units of red blood cells. »
Preparation of human red blood cells used to detect or identify blood-group antibodies for blood group determination. »
Cell biology concerned with structure and function of erythrocytes. »
A type of evergreen tree with hard fragrant wood that is a member of the cypress family. The oil from the wood… »
Trifolium pratense. A plant with flowers that has been used in some cultures to treat certain medical problems. It is being studied… »
The fruit of the jujube plant. It has been used in some cultures to treat certain medical problems. »
The inner bark of this plant has been used in some cultures to treat certain medical problems. It may have antioxidant… »
Lay term applied to any condition with dilation of conjunctival or ciliary blood vessels; innumerable causes, especially irritation and infection. »
A type of striated skeletal muscle fiber that contracts slowly and contains high amounts of mitochondria, myoglobin and sarcoplasm. »
An abrupt onset drug reaction characterized by a red rash that involves the face, neck, and upper torso. »
A risk factor for colorectal, stomach, and pancreatic cancer. »
An optic examination in which an ophthalmoscope or retinoscope is placed approximately 30cm from the eye to visualize whether a reddish hue… »
The killing of target cells by changing the natural specificity of cytotoxic T cells by the use of an antibody or other… »
A chemical reaction that takes place between an oxidizing substance and a reducing substance. The oxidizing substance loses electrons in the reaction,… »
A gel formulation containing reduced glutathione, L-cysteine, and anthocyanins with potential antioxidant, immunostimulating, and chemoprotective properties. Reduced glutathione is the primary cellular… »
A chemical reaction that takes place when a substance comes into contact with hydrogen or another reducing substance. »
Surgery performed to reduce the size of the breast. »
Undertake epidemiologic research to reduce or prevent the occurrence of OIs in HIV-infected persons. »
The attribute of being superfluous and unneeded. »
A type of cell that appears in people with Hodgkin disease. The number of these cells increases as the disease advances. … »
Reelin (3460 aa, ~388 kDa) is encoded by the human RELN gene. This protein is involved in both neuronal development and… »
Reelin is an extracellular protein secreted by neurons. Reeler mice with a defective Reelin gene exhibit neuronal abnormalities in development. … »
An orally bioavailable selective MEK inhibitor with potential antineoplastic activity. Refametinib specifically inhibits mitogen-activated protein kinase kinase 1 (MAP2K1 or MAPK/ERK kinase… »
A reference associated with a particular comment. »
The date and time of a specific reference point. »
A document that provides pertinent details for consultation about a subject. »
A point in time that indicates the cessation of an event. »
A sequence of characters that represents a reference identification. »
An object oriented information model to harmonize the definition of HL7 messages across different application domains. »
In medicine, a set of values that a doctor uses to interpret a patient’s test results. The reference interval for a… »
Something referred to; the object of a reference. »
A time frame that is of value for its relationship to a notable event. »
A specified location to which measurements are referred. »
In medicine, a set of values that a doctor uses to interpret a patient’s test results. The reference range for a… »
A region of interest in an image chosen for comparison purposes because its uptake properties have some desired feature. »
The possible or expected results that can be obtained by observing, monitoring, measuring or otherwise qualitatively or quantitatively recording one or more… »
Additional description of the reference result. »
Specifies whether the result applies to when the subject had abstained from eating when the specimen is obtained. »
Data or information that is determined by an act of observation. »
A coded value specifying the type of subjects to which this reference result applies. EXAMPLE(S): adult males, adult females, minor males, minor… »
A coded value specifying the kind of reference, i.e. how it is to be used or what its purpose is. EXAMPLE(S): normal… »
A coded value specifying the anatomic location that is the focus of a reference result. »
A coded value specifying the side of the body (or a paired organ) that is a target site for a result. … »
A coded value specifying the kind of reference result. »
A point in time that indicates the beginning of an event. »
The point in time that acts as a fixed reference point to an event. »
A citation in an external publication that refers to results of this study. »
A bibliographical reference in a format acceptable to the registration authority. »
The textual representation of the linked page. »
A unique symbol that establishes identity to a publication that cites this study's results. »
A non-unique textual identifier specifying the source of the publication identifier. »
A complete reference to a website (including http://) that is directly relevant to the study. »
In medicine, a set of values that a doctor uses to interpret a patient’s test results. The reference values for a… »
In medicine, the act of a doctor in which a patient is sent to another doctor for additional healthcare services. »
A pathologist that directs a patient to an additional source of medical expertise for assistance, examination, information, or treatment. »
A physician that directs a patient to an additional source of medical expertise for assistance, examination, information, or treatment. »
The spectroscopic analysis of light reflected from a polished sample. The peaks of reflectance/transmittance occur in the same spectral region where… »
A component of a time-of-flight mass spectrometer that uses a static electric field to reverse the direction of travel of the ions… »
Epilepsy triggered by an external stimulus or an internal mental process. Photosensitive epilepsy is the most common form of reflex epilepsy. … »
A component of the Apgar score, it is the numerical value assigned to the neonate's response to stimuli, such as a mild… »
A rare neurologic syndrome characterized by burning pain, tenderness, swelling, and changes in the skin color and temperature of a body part… »
A relation in which each element is in relation to itself. »
A type of massage in which different amounts of pressure are applied to specific points on the feet or hands. These… »
Issue associated with a backward or return flow. »
A defect in the focusing of light on the retina as in astigmatism, myopia, or hyperopia. »
The cornea and lens of your eye helps you focus. Refractive errors are vision problems that happen when the shape of… »
An optical instrument that can be used to determine the refractive index of a sample. »
A method to measure the refractive index (propensity for light to bend) of a sample. »
In medicine, describes a disease or condition that does not respond to treatment. »
Spinal cord neoplasm in adulthood which is resistant to treatment. »
Adult T-cell leukemia/lymphoma that is resistant to treatment. »
Anaplastic large cell lymphoma resistant to treatment. »
A myelodysplastic syndrome characterized mainly by dysplasia of the erythroid series. Refractory anemia is uncommon. It is primarily a disease… »
A myelodysplastic syndrome characterized by the presence of 5-19% myeloblasts in the bone marrow or 2-19% blasts in the peripheral blood. It… »
Refractory anemia with excess blasts in transformation (RAEB-T) is characterised by dysplastic features of the myeloid and usually erythroid progenitor cells in… »
A provisional entity that encompasses cases with morphologic and clinical characteristics of refractory anemia with ring sideroblasts, marked thrombocytosis, and abnormal… »
A myelodysplastic syndrome characterized by an anemia in which 15% or more of the erythroid precursors are ringed sideroblasts. The ring… »
Angioimmunoblastic T-cell lymphoma resistant to treatment. »
B-lymphoblastic lymphoma resistant to treatment. »
B-cell non-Hodgkin lymphoma that is resistant to treatment. »
Brain neoplasm resistant to treatment. »
Burkitt lymphoma that is resistant to treatment. »
Cancer that does not respond to treatment. The cancer may be resistant at the beginning of treatment or it may become resistant… »
Cancer that does not respond to treatment. The cancer may be resistant at the beginning of treatment, or it may become resistant… »
Central nervous system neoplasm resistant to treatment. »
Spinal cord neoplasm in childhood which is resistant to treatment. »
Chronic lymphocytic leukemia that is resistant to treatment. »
The most common subtype of the myelodysplastic syndromes affecting children. It is characterized by persistent cytopenia with less than 5% blasts in… »
A myelodysplastic syndrome characterized by bi-cytopenia or pancytopenia and dysplastic changes in 10% or more of the cells in two or more… »
A myelodysplastic syndrome characterized by bi-cytopenia or pancytopenia, dysplastic changes in 10% or more of the cells in two or more of… »
A myelodysplastic syndrome characterized by dysplastic changes involving only one myeloid cell lineage in the bone marrow. It primarily affects older adults… »
Diffuse large B-cell lymphoma that is resistant to treatment. »
A disease that resists treatment. »
Intestinal T-cell lymphoma that is resistant to treatment. »
Follicular lymphoma grade I, II, III that is resistant to treatment. »
Hairy cell leukemia that is resistant to treatment. »
High grade B-cell lymphoma Burkitt-like lymphoma resistant to treatment. »
Hodgkin lymphoma resistant to treatment »
Hodgkin lymphoma lymphocyte depleted, resistant to treatment. »
Lymphoplasmacytic lymphoma resistant to treatment. »
Malignant testicular germ cell tumor that is resistant to treatment. »
Mantle cell lymphoma resistant to treatment. »
Mature T-cell and NK-cell non-Hodgkin Lymphoma resistant to treatment. »
Primary mediastinal large B-cell lymphoma resistant to treatment. »
Mycosis fungoides resistant to treatment. »
A myelodysplastic syndrome characterized by the presence of at least 10% dysplastic neutrophils in the bone marrow or the peripheral blood. … »
Nodal marginal zone B-cell lymphoma resistant to treatment. »
A non-Hodgkin lymphoma which does not respond to treatment. »
Peripheral T-cell lymphoma not otherwise specified resistant to treatment. »
A plasma cell neoplasm that is resistant to treatment. »
B-cell small lymphocytic lymphoma that is resistant to treatment. »
Spinal cord neoplasm resistant to treatment. »
T-lymphoblastic leukemia/lymphoma resistant to treatment »
T-cell non-Hodgkin lymphoma resistant to treatment. »
A myelodysplastic syndrome characterized by the presence of at least 10% dysplastic megakaryocytes, found within at least 30 megakaryocytes examined in the… »
A commercial combination preparation, by Allergan, containing mineral oil and white petrolatum. Refresh PM Lubricant, an ointment, is used to moisturize and… »
Sample is refrigerated and not tested immediately. »
A specimen that has been kept or preserved at a low temperature in a refrigerator. »
The Reference Sequence (RefSeq) collection aims to provide a comprehensive, integrated, non-redundant set of sequences, including genomic DNA, transcript (RNA), and protein… »
A rare autosomal recessive disorder characterized by abnormalities in the breakdown of phytanic acid and impaired growth of myelin sheaths. Signs and… »
A person who has left his country of residence, and cannot return for fear of human-rights related persecution. »
A temporary, often makeshift shelter for persons displaced by war, political oppression, or for religious beliefs. »
An individual that has fled a country for their own safety which has a high occurrence of tuberculosis. »
The determination of the amount of the RANTES (regulated on activation, normally, T-cell expressed, and secreted) chemokine present in a sample. … »
This gene may be involved in pancreatic cell proliferation and differentiation. »
Human REG3A wild-type allele is located in the vicinity of 2p12 and is approximately 3 kb in length. This allele, which encodes… »
Lacking consideration or without thoughtful attention. »
A substance being studied in the treatment of certain types of skin rash and skin pain in cancer patients. The ingredients of… »
Regenerating islet-derived protein 3-alpha (175 aa, ~19 kDa) is encoded by the human REG3A gene. This protein may be involved in pancreatic… »
In biology, regrowth of damaged or destroyed tissue or body part. »
A morphologic finding indicating epithelial regrowth following injury. »
A field of medicine devoted to treatments in which stem cells are induced to differentiate into the specific cell type required to… »
An area or portion of something with more or less definite boundaries designed or specified according to some established biological, administrative, economic,… »
A medulloblastoma characterized by the loss of one of the p13 regions of chromosome 17. Loss of genetic material of chromosome… »
A pheochromocytoma that invades surrounding tissues adjacent to the adrenal glands. »
A temporary loss of feeling or awareness in a part of the body, such as an arm or a leg, caused by… »
The administration of pharmaceutical agents intended to produce loss of sensation in a particular anatomical region. »
Refers to cancer that has grown beyond the original (primary) tumor to nearby lymph nodes or organs and tissues. »
Treatment with anticancer drugs directed to a specific area of the body. »
A disease or condition that extends beyond the site and spreads into adjacent tissues and regional lymph nodes. »
Mechanism to facilitate partnerships between NCI-Designated Comprehensive Cancer Centers and research institutions to provide patients and populations with improved access to… »
A condition in which the gastrointestinal tract is inflamed over a long period of time. Regional enteritis usually affects the small… »
A well differentiated neuroendocrine tumor (carcinoid tumor) that arises from the gastrointestinal system and has spread into adjacent tissues and regional lymph… »
A tumor deposit found in a resected specimen in the fatty adjacent tissue and not contained within lymphoid tissue. »
In oncology, a lymph node that drains lymph from the region around a tumor. »
A surgical procedure to remove some of the lymph nodes that drain lymph from the area around a tumor. The lymph nodes… »
Abnormal malignant growth of cells in the ureter without spread to any other region. »
Abnormal malignant growth of cells in the urethra without spread to any other region. »
A neuroblastoma confined to a specific anatomic region without evidence of dissemination. »
Carcinoma of the ureter without spread to any other region. »
The act of listing or recording officially. Listed or recorded officially; officially qualified or enrolled. »
A health professional with special training in the use of diet and nutrition to keep the body healthy. A registered dietitian may… »
A licensed health care worker who performs the administrative and clinical tasks that keep the offices of physicians, podiatrists, chiropractors, and other… »
Registered Nurse (R.N.) - a nurse who has graduated from an accredited registered nursing program, has passed the state exam for licensure,… »
A registered nurse who has received special training and can perform many of the duties of a physician. »
A person trained to formulate and dispense drugs or medications through completion of an accredited university program in pharmacy. Licensure is required… »
The act of listing or recording officially. »
An organization authorized to register a registry item. »
The service of recording subject participation on a study. The service may include allocation to an Arm or a portion of an… »
A sequence of digits or characters used to identify a particular telephone, fax, or email of a registration center. »
A person that is responsible for the integration and collation of subject information and participation throughout the duration of the clinical trial,… »
Specifies whether registration to an event or activity is mandatory. »
A user who, on behalf of a sponsor, will manage and process the Investigator registrations. »
An information system, RENI (REgistry Nomenclature Information System) is the extended electronic version of the publications 'International Classification of Rodent Tumours'. The… »
A drug that increases the motility (movements and contractions) of the stomach and upper intestine. It is used to treat certain stomach… »
A drug used to treat colorectal cancer that has spread to other parts of the body and has not gotten better with… »
Animals inoculated with the regressing strain of Friend virus exhibited an initial pathologic response identical to that induced by conventional strains of… »
A skin lesion characterized by the disappearance of the melanoma cells from the primary melanoma site. The disappearance of the malignant cells… »
A decrease in the size of a tumor or in the extent of cancer in the body. »
Regression analysis provides a "best-fit" mathematical equation for the relationship between the dependent variable (response) and independent variable(s) (covariates). There are two… »
A question about whether an individual regrets or regretted having a bone marrow transplant. »
A question about whether an individual regrets or regretted smoking. »
Connective tissue mainly composed of parallel collagenous fibers leaving little room for embedded fibroblasts. This tissue has high tensile strength, but elasticity… »
A consistent rhythmic pattern of uterine muscle tightening that occurs at regular intervals for the same duration of time. »
The nature and pattern of occurrence for the uterine contractions during labor. »
A company, institution or organization that develops, manufactures, distributes or has responsibility for a regulated product. »
A unique identification number assigned to a specific regulated industry entity. »
A process that involves the proteolysis of an integral membrane protein at a site that is within its transmembrane domain. This cleavage… »
An article subject to the jurisdiction of the Food and Drug Administration, including any food or drug as defined in section 201(g)… »
A rule or order issued by an authority stating what may or may not be done or how something must be… »
Any physiologic response that results in an increased number of active antibodies circulating in the plasma. This process is involved in tuning… »
Nicotinic acetylcholine receptors are essential for neuromuscular signaling and are also expressed in non-neuronal tissues, where their function is less clear. … »
A process that is involved in modulating the rate or frequency of cell death. »
Intracellular or extracellular processes that control, manage, or govern adoption or maintenance of sustained or transient changes in cell shape. »
Intracellular or extracellular processes that control, manage, or govern adoption, production, or maintenance of sustained or transient changes in cell size. … »
Cholesterol is essential for life but a key in the development of heart disease. Cholesterol homeostasis is achieved through regulation of cholesterol… »
Regulation of Exocytosis consists of subcellular biochemical pathways and mechanisms that control release of cellular ingredients packaged in membrane-bound vesicles that fuse… »
Nuclear Division Alteration involves a change in the quality of the existing state of the complex cell division process (consisting of prophase,… »
Any process that modulates the rate, frequency or extent of platelet aggregation via adhesion molecules. »
Biochemical and cellular mechanisms involved in Regulation of Proteolysis ensure that hydrolysis of one or more peptide bonds within target proteins by… »
Something that controls the rate or manner in which a process progresses or a product is formed. »
Any device designed to control a process or condition. »
Induced in response to several activation signals and encoded by B-cell specific immediate early human RGS1 Gene (RGS Family), 196-aa 22.5-kDa Regulator… »
Expressed most in lung, placenta, liver, and heart by human RGS19 Gene (RGS Family), membrane-bound fatty acylated 217-aa 25-kDa Regulator of G-protein… »
Encoded by human RGS2 Gene (RGS Family), 211-aa 24-kDa Regulator of G-Protein Signaling 2 is a basic HLH phosphoprotein containing 1 RGS… »
Encoded by human RGS3 Gene (RGS Family), 519-aa 56.6-kDa cytosolic Regulator of G-Protein Signaling 3 contains 1 RGS domain and is likely… »
Regulator of G-protein signaling 4 (205 aa, ~23 kDa) is encoded by the human RGS4 gene. This protein is involved in the… »
Regulator of G-protein signaling 5 (5181 aa, ~21 kDa) is encoded by the human RGS5 gene. This protein plays a role in… »
The business of a regulatory agency. »
A collection of submissions related to a particular regulated product that are grouped together for regulatory purposes and can be referenced in… »
A subset category identified within a larger group of regulatory application documents. A document subtype provides more specific context for the… »
A unique symbol that establishes identity of the regulatory application. »
The party who submits a marketing application to FDA for approval of a drug, device, or biologic product. An applicant is the… »
The date and time span for when the regulatory application sponsor is active. »
The primary category of an official application to the regulatory agency. It can cause specific types of regulatory requests. The type… »
A coded value specifying the kind of regulatory application. »
A unique identifier assigned to a submitted application by the regulatory authority. »
A regulatory action or inaction undertaken by the regulatory authority as a result of a submission analysis and evaluation. »
A coded value specifying the regulatory designation made by the regulatory authority. »
The date (and time) on which this particular assessment is completed. »
A unique symbol that establishes identity of the regulatory assessment. »
A coded value specifying the rationale for a regulatory designation. »
A coded value specifying the approval process used by the regulatory authority. EXAMPLE(S): FDA's Center for Devices and Radiological Health (CDRH) Process,FDA's… »
A geopolitical organization responsible for regulating products used in health care. »
The date and time span for when the regulatory authority is active. »
A coded value specifying the type of governance over which an authority has to make laws and enforce them. »
A coded value specifying the geographical area or limits an authority has to make laws and enforce them. »
A person that is responsible for ensuring compliance with government regulations and interacts with the regulatory agencies regarding toxicity, protocol administration, and… »
Any DNA sequence involved in the regulation of genetic processes such as transcription and replication. »
Type of the regulatory element e.g. promoter, polyA signal. »
Regulatory Genes encode products that regulate or circumscribe the activity of diverse cellular functions. »
An elaboration of the known or inferred interactions controlling the expression of a product. »
A process that acts to control the rate or manner in which another process progresses or a product is formed. »
Encoded by Regulatory Genes, Regulatory Proteins regulate or circumscribe the activity of many cellular functions. »
Regulatory protein E2 (365 aa, ~42 kDa) is encoded by the human papillomavirus type 16 E2 gene. This protein plays a role… »
Regulatory protein E2 (365 aa, ~42 kDa) is encoded by the human papillomavirus type 18 E2 gene. This protein plays a role… »
Single Nucleotide Polymorphism in Regulatory Sequences (Regulatory Region SNP) consists of a variation at an appreciable frequency between individuals of a single… »
A type of report required by a regulatory agency. »
The Regulatory sub-domain is intended for those involved in the creation and review of submissions to regulatory authorities. The majority of business… »
An assembly of one or more regulatory submission units supporting a specific regulatory purpose or decision. In most cases, the compilation of… »
A date on the submission form or cover letter, whichever is the latest. »
Physical media documenting the date and time when a regulatory submission is received in the FDA Document Room. This is an official… »
A particular category of a regulatory submission regarded as having particular characteristics, purposes, and causing different regulatory requests. »
A unique identifier assigned to a submittion by the regulatory authority. Submission serial number, volume number, electronic folder, or file name are… »
A particular category of a regulatory submission regarded as having particular characteristics, purposes, and causing different regulatory requests. »
A type of immune cell that blocks the actions of some other types of lymphocytes, to keep the immune system from becoming… »
Regulatory-associated protein of mTOR (1335 aa, ~149 kDa) is encoded by the human RPTOR gene. This protein is involved in regulating cell… »
Flow in the opposite direction from normal, as the casting up of undigested food or gas from the stomach, or the backward… »
In medicine, a process to restore mental and/or physical abilities lost to injury or disease, in order to function in a normal… »
Rehabilitation nursing is a specialty devoted to assisting individuals of all ages and cultural backgrounds to accomplish the tasks of daily living… »
Special healthcare services that help a person regain physical, mental, and/or cognitive (thinking and learning) abilities that have been lost or impaired… »
A healthcare professional who helps people recover from an illness or injury and return to daily life. Examples of rehabilitation specialists are… »
The study in the field of restoring the ability to live and work as normally as possible after a disabling injury or… »
An alternative medical practice. The practitioners of reiki believe that health and disease are a matter of the life force being… »
A surgical procedure that places something in the body that was previously lost or removed. »
Clinical diagnosis of a repeated infarction of an organ during a hospitalization. »
The infusion of autogenic body fluid that has previously been withdrawn from the patient. »
A rare, reactive inflammatory disorder seen following bacterial infection. It predominantly affects males aged 20-40. Individuals with HLA-B27 antigen are estimated to… »
This gene is involved in transcriptional regulation and signal transduction through the nuclear factor kappa B NFKB signal transduction pathway. »
Human REL wild-type allele is located within 2p13-p12 and is approximately 41 kb in length. This allele, which encodes C-Rel proto-oncogene protein,… »
The rel/NF-kB family of transcription factors regulates the activity of genes involved in the immune response, hematopoiesis, and inflammation. NF-kB is… »
Human RELA wild-type allele is located in the vicinity of 11q13 and is approximately 9 kb in length. This allele, which encodes… »
RelA-associated inhibitor (828 aa, ~89 kDa) is encoded by the human PPP1R13L gene. This protein is involved in the modulation of cellular… »
The return of a disease or the signs and symptoms of a disease after a period of improvement. Relapse also refers to… »
Relapse from complete response of multiple myeloma or plasma cell leukemia requires one or more of the following: reappearance of serum or… »
In cancer, the length of time after primary treatment for a cancer ends that the patient survives without any signs or symptoms… »
The short name for a related domain. »
A piece of data that is related to another piece of data. »
An indication or description that a relationship to cancer exists. »
A characteristic used to qualify the adverse event as unclassifiable in term of its relation to the medical intervention. According to WHO… »
An abstraction belonging to or characteristic of a point or period to something that refers or points to an interval of time… »
A boolean operator used to specify a greater-than, less-than, or equal-to relationship. »
A state of connectedness between people, objects, or events; to be associated or connected with something. »
The attribute that pertains to an affiliation between persons, places, things or events. »
The kind of affiliation between persons, places, things or events. »
A factor assigned to a type of ionizing radiation in converting absorbed dose measured in grays to a biologically equivalent dose measured… »
Dating methods that determine time with respect to stratigraphic position, for example deeper layers being older, or with respect to some changing… »
A measure of the odds of an event happening in one group compared to the odds of the same event happening in… »
A measure of the risk of a certain event happening in one group compared to the risk of the same event happening… »
A way of comparing survival of people who have a specific disease with those who don't. The percentage of survivors is usually… »
