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MITOMYCIN
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I. (noun)
Sense 1
Meaning:
A complex of antibiotic substances obtained from a streptomyces bacterium; one form (trade name Mutamycin) shows promise as an anticancer drug
Synonyms:
Classified under:
Nouns denoting man-made objects
Hypernyms ("mitomycin" is a kind of...):
antibiotic; antibiotic drug (a chemical substance derivable from a mold or bacterium that can kill microorganisms and cure bacterial infections)
Context examples:
Bioreduced mitomycin A generates oxygen radicals, alkylates DNA, and produces interstrand DNA cross-links, thereby inhibiting DNA synthesis.
(Mitomycin A, NCI Thesaurus)
In the one-way MLC test, the lymphocytes from one of the individuals are inactivated (usually by treatment with mitomycin C or radiation) thereby allowing only the untreated remaining population of cells to proliferate in response to foreign histocompatibility antigens.
(Mixed Lymphocyte Reaction Test, NCI Thesaurus)
HL-60/MX2 cells are cross-resistant to etoposide, teniposide, bisantrene, dactinomycin, 4'-(9-acridinylamino)methane- sulfon-m-anisidide, and the anthracyclines daunorubicin and doxorubicin but retain sensitivity to the Vinca alkaloids vincristine and vinblastine, melphalan, mitomycin C and cisplatin.
(HL-60/MX2, NCI Thesaurus)
A semisynthetic water-soluble disulfide derivative of the antineoplastic antibiotic mitomycin C. Activated by serum and glutathione, KW-2149 causes interstrand DNA cross-links and DNA-protein cross-links, resulting in single-strand DNA breaks and inhibition of DNA synthesis.
(KW-2149, NCI Thesaurus)
Mitomycin C comes from bacteria.
(mitomycin C, NCI Dictionary)
BRCA1 acts as a ubiquitin ligase targeting the protein FancD2 that activates checkpoint control, integrating the ATM response to ionizing radiation and the FA response to cross-linking agents like mitomycin C. Mutation of one of the several components of the FA complex involved in maintaining integrity of the genome leads to the condition Fanconi anemia.
(Cancer Susceptibility Pathway, NCI Thesaurus/BIOCARTA)
HL-60/MX1 cells are cross resistant to etoposide, teniposide, bisantrene, actinomycin, 4'-(9-acridinylamino)methane-sulfon-m-anisidide, and the anthracyclines daunorubicin and doxorubicin but retain sensitivity to the Vinca alkaloids vincristine and vinblastine, melphalan, mitomycin C and cisplatin.
(HL-60/MX1, NCI Thesaurus)
Folate receptor-targeted vinca alkaloid/mitomycin C EC0225 contains two potent cytotoxic agents, a vinca alkaloid and mitomycin C, linked to a single folate molecule.
(Folate Receptor-Targeted Vinca Alkaloid/Mitomycin C EC0225, NCI Thesaurus)
All mitomycins have the backbone of methyl, aziridine, pyrrolo, indole, and dione moieties.
(Mitomycin Antineoplastic Antibiotic, NCI Thesaurus)
Mitomycin A is more toxic than mitomycin C due to increased and nonselective DNA cross-linking in both aerobic and hypoxic cells.
(Mitomycin A, NCI Thesaurus)
