| Health / Medical Topics |
Mitoxantrone
Pronunciation
Definition 1
A drug used to treat advanced prostate cancer that does not respond to hormones, adult acute nonlymphocytic leukemia, and advanced or chronic multiple sclerosis. It is also being studied in the treatment of other cancers. It belongs to the family of drugs called antitumor antibiotics. Also called Novantrone. (NCI Dictionary)
Definition 2
An anthracenedione antibiotic with antineoplastic activity. Mitoxantrone intercalates into and crosslinks DNA, thereby disrupting DNA and RNA replication. This agent also binds to topoisomerase II, resulting in DNA strand breaks and inhibition of DNA repair. Mitoxantrone is less cardiotoxic compared to doxorubicin. (NCI Thesaurus)
YOU MAY ALSO LIKE
The mitotic/spindle checkpoint ensures that all replicated chromatids are properly connected to opposing spindle poles before separation (anaphase) can begin. The proteins…
One of the central features of mitotic cell division is the formation of the spindle that segregates chromosomes into each daughter…
Mitotic spindle assembly checkpoint protein MAD2A (205 aa, ~24 kDa) is encoded by the human MAD2L1 gene. This protein is involved in…
The faithful segregation of genetic information requires highly orchestrated changes of chromosome structure during the mitotic cell cycle. The linkage between duplicated…
Any type of recombination occuring within somatic cells and involving possible exchange and frequent loss of segments of DNA by either homologous…
A measure of how fast cancer cells are dividing and growing. To find the mitotic rate, the number of cells dividing in…
