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MUTANT
| Pronunciation (US): |  | (GB): | |
I. (noun)
Sense 1
Meaning:
An animal that has undergone mutation
Classified under:
Hypernyms ("mutant" is a kind of...):
animal; animate being; beast; brute; creature; fauna (a living organism characterized by voluntary movement)
Derivation:
mutant (tending to undergo or resulting from mutation)
mutate (undergo mutation)
Sense 2
Meaning:
(biology) an organism that has characteristics resulting from chromosomal alteration
Synonyms:
mutant; mutation; sport; variation
Classified under:
Hypernyms ("mutant" is a kind of...):
being; organism (a living thing that has (or can develop) the ability to act or function independently)
Domain category:
biological science; biology (the science that studies living organisms)
Hyponyms (each of the following is a kind of "mutant"):
freak; lusus naturae; monster; monstrosity (a person or animal that is markedly unusual or deformed)
Derivation:
mutant (tending to undergo or resulting from mutation)
mutate (undergo mutation)
II. (adjective)
Sense 1
Meaning:
Tending to undergo or resulting from mutation
Example:
a mutant gene
Classified under:
Relational adjectives (pertainyms)
Pertainym:
mutation ((genetics) any event that changes genetic structure; any alteration in the inherited nucleic acid sequence of the genotype of an organism)
Derivation:
mutant (an animal that has undergone mutation)
mutant ((biology) an organism that has characteristics resulting from chromosomal alteration)
mutate (undergo mutation)
Context examples:
Subsequently, autologous EBV-specific CTLs are transduced with retroviral vectors expressing the mutant type II TGF-beta dominant-negative receptor (DNR), which blocks signaling by all three TGF-beta isoforms, and the HER2 CAR.
(Autologous TGFbeta-Resistant HER2/EBV-Specific Cytotoxic T Lymphocytes, NCI Thesaurus)
Colorectal mutant cancer protein (829 aa, ~93 kDa) is encoded by the human MCC gene.
(Colorectal Mutant Cancer Protein, NCI Thesaurus)
Moreover, the mutant mice were dramatically better at standing up after diazepam-induced stumbles, in fact, some appeared resistant to stumbling.
(‘Sticky’ gene may help Valium calm nerves, National Institutes of Health)
Roundworm mutants of pals-22 always have IPR genes on, which causes increased tolerance of heat shock and other types of stress.
(New Pathway for Handling Stress Discovered, The Titi Tudorancea Bulletin)
The mutant rats consumed much greater quantities of nicotine at each dose.
(Nicotine addiction linked to diabetes through a DNA-regulating gene in animal models, National Institutes of Health)
Underlying such impaired neuronal growth and function, the researchers discovered that the mutant SETD1A gene disrupted regulation of many other genes with which it is networked.
(Schizophrenia risk gene linked to cognitive deficits in mice, National Institutes of Health)
In contrast, the researchers prevented cell death when they engineered the cells to also make a mutant s15 protein that could not be tagged by LRRK2.
(Too much protein may kill brain cells as Parkinson’s progresses, NINDS)
Similarly, the NIH researchers found that mutant MDA5 in the girl’s respiratory tissues could not recognize HRVs, preventing her immune system from producing protective signaling proteins called interferons.
(Scientists discover rare genetic susceptibility to common cold, National Institutes of Health)
A neuroattenuated, replication-restricted, ICP34.5 deleted (RL1 gene)-mutant herpes simplex virus (HSV) type I, constructed from wild-type strain 17, with potential oncolytic activity.
(Oncolytic HSV1716, NCI Thesaurus)
An aza-dipeptide analogue with a bis-aryl substituent on the (hydroxethyl)hydrazine moiety with activity against both wild type and mutant forms of HIV protease.
(Atazanavir, NCI Thesaurus)
