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MUTATION
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I. (noun)
Sense 1
Meaning:
A change or alteration in form or qualities
Classified under:
Hypernyms ("mutation" is a kind of...):
alteration; change; modification (an event that occurs when something passes from one state or phase to another)
Derivation:
mutational (of or relating to or resulting from mutation)
Sense 2
Meaning:
(genetics) any event that changes genetic structure; any alteration in the inherited nucleic acid sequence of the genotype of an organism
Synonyms:
chromosomal mutation; genetic mutation; mutation
Classified under:
Nouns denoting natural events
Hypernyms ("mutation" is a kind of...):
alteration; change; modification (an event that occurs when something passes from one state or phase to another)
Meronyms (parts of "mutation"):
mutagenesis (an event capable of causing a mutation)
Domain category:
genetic science; genetics (the branch of biology that studies heredity and variation in organisms)
Hyponyms (each of the following is a kind of "mutation"):
deletion ((genetics) the loss or absence of one or more nucleotides from a chromosome)
inversion ((genetics) a kind of mutation in which the order of the genes in a section of a chromosome is reversed)
transposition ((genetics) a kind of mutation in which a chromosomal segment is transfered to a new position on the same or another chromosome)
gene mutation; point mutation ((genetics) a mutation due to an intramolecular reorganization of a gene)
reversion ((genetics) a return to a normal phenotype (usually resulting from a second mutation))
saltation ((genetics) a mutation that drastically changes the phenotype of an organism or species)
Derivation:
mutate (undergo mutation)
mutational (of or relating to or resulting from mutation)
Sense 3
Meaning:
(biology) an organism that has characteristics resulting from chromosomal alteration
Synonyms:
mutant; mutation; sport; variation
Classified under:
Hypernyms ("mutation" is a kind of...):
being; organism (a living thing that has (or can develop) the ability to act or function independently)
Domain category:
biological science; biology (the science that studies living organisms)
Hyponyms (each of the following is a kind of "mutation"):
freak; lusus naturae; monster; monstrosity (a person or animal that is markedly unusual or deformed)
Derivation:
mutate (undergo mutation)
mutational (of or relating to or resulting from mutation)
Context examples:
An acute myeloid leukemia with mutation of the CEBPA gene.
(Acute Myeloid Leukemia with Mutated CEBPA, NCI Thesaurus)
An acute myeloid leukemia with mutation of the nucleophosmin gene.
(Acute Myeloid Leukemia with Mutated NPM1, NCI Thesaurus)
The presence of TP53 mutations indicates worse prognosis.
(Adenocarcinoma of the Gastroesophageal Junction, NCI Thesaurus)
Inactivating mutations of APC cause accumulation of beta-Catenin, which binds TCF4 and increases transcription of target genes (e.g., c-MYC) and binds GSK3-beta in the WNT signaling pathway.
(Adenomatous Polyposis Coli Protein, NCI Thesaurus)
A term referring to acute myeloid leukemias associated with gene mutations most often of the FLT3, NPM1, and CEBPA genes.
(Acute Myeloid Leukemia with Gene Mutations, NCI Thesaurus)
A point mutation involving the substitution of Cytosine (a pyrimidine base) for Adenosine (a purine base) in a DNA sequence from eukaryotic or prokaryotic organisms.
(Adenosine to Cytosine Transversion Abnormality, NCI Thesaurus)
Mutation of the gene is associated with spondyloenchondrodysplasia with immune dysregulation.
(ACP5 wt Allele, NCI Thesaurus)
A point mutation involving the substitution of Thymidine (a pyrimidine base) for Adenosine (a purine base) in a DNA sequence from eukaryotic or prokaryotic organisms.
(Adenosine to Thymidine Transversion Abnormality, NCI Thesaurus)
Mutation of the gene is associated with dystonia juvenile-onset and Baraitser-Winter syndrome type 1.
(ACTB wt Allele, NCI Thesaurus)
Mutation of the gene is linked to Keutel syndrome.
(MGP wt Allele, NCI Thesaurus)
