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Nerve Growth Factor Receptor
Definition 1
Nerve growth factor receptor (NGFR) is also referred to as p75(NTR) due to its molecular mass and its ability to bind at low affinity not only NGF, but also other neurotrophins, including brain-derived neurotrophic factor (BDNF), neurotrophin-3 (NTF3), and neurotrophin-4/5 (NTF5). NGFR was the first member of the large superfamily of tumor necrosis factor receptors. The identification of this superfamily helped elucidate some of the biologic functions of NGFR, including its ultimate involvement in the nuclear factor kappa-B (NFKB) and apoptosis pathways. As a monomer, NGFR binds NGF with low affinity. Higher affinity binding is achieved by association with higher molecular mass, low-affinity neurotrophin receptors, namely the tropomyosin receptor kinases, TRKA (NTRK1), TRKB (NTRK2), and TRKC (NTRK3). (OMIM) (NCI Thesaurus)
Definition 2
Neurotrophins and their receptors regulate development of the central and peripheral nervous systems. NGFR binds at low affinity to NGF, BDNF, NTF3, and NTF5. Higher affinity binding is achieved by association with the low-affinity neurotrophin receptors TRKA, TRKB, and TRKC. TRKA is specific for or 'preferred by' NGF. NTF3 also binds to TRKA. NGF stimulates phosphorylation of the TRK protein. TRK is expressed in monocytes, suggesting that, in addition to its neurotrophic function, NGF is an immunoregulatory cytokine acting on monocytes. (from OMIM 191315 and NCI) (NCI Thesaurus)
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