| Health / Medical Topics |
Neuro-Oncological Ventral Antigen 1
Encoded by human NOVA1 Gene (Nova Family), the 510-amino acid 52 kD NOVA-1 Protein is a brain neuron-specific nuclear RNA-binding protein. NOVA-1 contains three KH domains and may regulate RNA splicing or metabolism in specific developing neurons. It binds RNA in a sequence-specific manner to regulate neuron-specific splicing of inhibitory receptor pre-mRNAs in postnatal motor neurons. Murine Nova1 specifically binds to the GLRA2 intronic (UCAUY)3 sequence motif. (from Swiss-Prot, OMIM, and NCI) (NCI Thesaurus)
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