| Health / Medical Topics |
Neuro-Oncological Ventral Antigen 2
Expressed in brain by human NOVA2 Gene, RNA-binding NOVA2 protein is recognized by the paraneoplastic syndrome antibody anti-Ri. NOVA1 and NOVA2 bind to similar RNA ligands with high affinity and may regulate RNA splicing. The NOVA2 KH3 domain interacts with single-stranded RNA; KH3 bound to stem loop RNA resembles a vise, with UCAC held between an invariant Gly-X-X-Gly motif and a variable loop. Tetranucleotide recognition is supported by an aliphatic alpha-helix/beta-sheet RNA-binding platform that mimics UG by making Watson-Crick-like hydrogen bonds with CA. (NCI Thesaurus)
YOU MAY ALSO LIKE
Encoded by human NOVA1 Gene (Nova Family), the 510-amino acid 52 kD NOVA-1 Protein is a brain neuron-specific nuclear RNA-binding protein. NOVA-1…
The components of the eye that are also part of the nervous system, including the retina and optic nerve.
Human NEURL wild-type allele is located in the vicinity of 10q25.1 and is approximately 98 kb in length. This allele, which encodes…
This gene is involved in development of the nervous system and protein turnover.
NEGF2 is a member of a highly conserved, developmentally regulated human gene family. The gene product exhibits neurite outgrowth-promoting activity and may…
Neurexin-1-beta (442 aa, ~47 kDa) is encoded by the human NRXN1 gene. This protein is involved in cell-cell interactions, cellular adhesion, signal…
