NFIC wt Allele

Definition 1

Widely expressed human NF-I Genes (CTF/NF-I Family) encode NF-I Proteins that contain a DWA/MH1 domain and bind TTGGCNNNNNGCCAA DNA palindromes in viral and cellular promoters as a homodimeric factor capable of activating transcription and replication. (NCI Thesaurus)

Definition 2

Human NFIC wild-type allele is located in the vicinity if 19p13.3 and is approximately 104 kb in length. This allele, which encodes nuclear factor 1 C-type protein, plays a role in both the modulation of transcription by RNA polymerase II and the activation of DNA replication. (NCI Thesaurus)

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