| Health / Medical Topics |
Nisoldipine
A dihydropyridine calcium channel blocking agent. Nisoldipine inhibits the transmembrane influx of extracellular calcium ions into myocardial and vascular smooth muscle cells, causing dilatation of the main coronary and systemic arteries and decreasing myocardial contractility. This agent also inhibits the drug efflux pump P-glycoprotein which is overexpressed in some multi-drug resistant tumors and may improve the efficacy of some antineoplastic agents. (NCI Thesaurus)
YOU MAY ALSO LIKE
Nischarin (1504 aa, ~167 kDa) is encoded by the human NISCH gene. This protein is involved in the regulation of signal…
Human NISCH wild-type allele is located in the vicinity of 3p21.1 and is approximately 38 kb in length. This allele, which encodes…
This gene is involved in imidazoline binding and signaling.
A kappa-opioid receptor agonist with edema relieving activity. Niravoline inhibits the scretion of the the antiduretic hormone vasopressin thereby causing a diuretic…
A drug used to treat recurrent ovarian epithelial, fallopian tube, or primary peritoneal cancers that have gotten better after treatment with anticancer…
An inhibitor of poly (ADP-ribose) polymerase (PARP) with potential antineoplastic activity. Niraparib inhibits PARP activity, enhancing the accumulation of DNA strand breaks…
