| Health / Medical Topics |
Nitric Oxide Synthase, Inducible
Induced by lipopolysaccharide, endotoxins, and cytokines and expressed as 2 alternative isoforms in liver, retina, bone cells, and airway epithelia by human NOS2A Gene (NOS Family), calcium/calmodulin stimulated homodimeric Nitric Oxide Synthase 2A binds FAD and FMN cofactors, contains a flavodoxin-like domain, requires BH4 which may stabilize the dimer, and synthesizes reactive free radical nitric oxide messenger (from L-arginine). NO has antimicrobial and antitumoral activities in macrophages. NOS2A binds SLC9A3R1. IL12 requires NOS2 to stimulate NK cell cytotoxicity and to activate STAT4 tyrosine-phosphorylation by TYK2 in innate immunity. Aspirin inhibits NOS2A. (NCI Thesaurus)
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