Philadelphia Chromosome Negative, BCR-ABL1 Positive Chronic Myelogenous Leukemia

A chronic myelogenous leukemia which does not have the characteristic t(9;22)(q34;q11.2) translocation but it has either a variant translocation or a cryptic translocation that can not be detected by conventional cytogenetic analysis. In such cases the BCR-ABL1 fusion gene is always detected by RT-PCR, FISH, or Southern blot analysis. (NCI Thesaurus)

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Philadelphia chromosome

An abnormality of chromosome 22 in which part of chromosome 9 is transferred to it. Bone marrow cells that contain the Philadelphia…

PHGDH wt Allele

Human PHGDH wild-type allele is located in the vicinity of 1p12 and is approximately 84 kb in length. This allele, which encodes…

PHGDH Gene

This gene plays a role in amino acid synthesis.

PHF6 wt Allele

Human PHF6 wild-type allele is located in the vicinity of Xq26.3 and is approximately 56 kb in length. This allele, which encodes…

PHF6 Gene

This gene plays a role in transcriptional regulation.

PHF23 wt Allele

Human PHF23 wild-type allele is located in the vicinity of 17p13.1 and is approximately 4 kb in length. This allele, which encodes…