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Phosphatidylinositol-3,4,5-Trisphosphate 3-Phosphatase and Dual-Specificity Protein Phosphatase PTEN
Definition 1
Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN (403 aa, ~47 kDa) is encoded by the human PTEN gene. This protein plays a role in signaling and as both a dual-specificity phosphoprotein phosphatase and a lipid phosphatase. (NCI Thesaurus)
Definition 2
A protein that helps control many cell functions, including cell division and cell death. Mutations (changes) in the gene that makes PTEN are found in many types of cancer and other diseases. It is a type of tumor suppressor protein. (NCI Dictionary)
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