PI3K Alpha/Beta Inhibitor BAY1082439

An orally bioavailable inhibitor of the class I phosphoinositide 3-kinase (PI3K) alpha and beta isoforms with potential antineoplastic activity. PI3K alpha/beta inhibitor BAY1082439 selectively inhibits both PI3K alpha, including mutated forms of PIK3CA, and PI3K beta in the PI3K/Akt/mTOR pathway, which may result in tumor cell apoptosis and growth inhibition in PI3K-expressing and/or PTEN-driven tumor cells. By specifically targeting class I PI3K alpha and beta, this agent may be more efficacious and less toxic than pan PI3K inhibitors. Dysregulation of the PI3K/Akt/mTOR pathway is frequently found in solid tumors and results in increased tumor cell growth, survival, and resistance to chemotherapy and radiotherapy. PIK3CA, one of the most highly mutated oncogenes, encodes the p110-alpha catalytic subunit of the class I PI3K. PTEN, a tumor suppressor protein and negative regulator of PI3K activity, is often mutated in a variety of cancer cells. (NCI Thesaurus)

YOU MAY ALSO LIKE

PI3K alpha Inhibitor INK1117

An orally bioavailable inhibitor of the class I phosphoinositide 3-kinase (PI3K) alpha isoform with potential antineoplastic activity. PI3K alpha inhibitor INK1117 selectively…

PI3K

A type of enzyme that transmits signals in cells and that helps control cell growth. Some tumors have higher-than-normal levels of…

PI3 wt Allele

Human PI3 wild-type allele is located in the vicinity of 20q13.12 and is approximately 2 kb in length. This allele, which encodes…

PI3 kinase

A type of enzyme that transmits signals in cells and that helps control cell growth. Some tumors have higher-than-normal levels of PI3…

PI3 Gene

This gene plays a role in the inhibition of elastase activity.

PI-88

A substance that is being studied in the treatment of cancer. It belongs to the family of drugs called antiangiogenesis agents. …