Pibrozelesin

A semisynthetic water-soluble derivative of the antineoplastic antibiotic duocarmycin B2. Activated by carboxyl esterase, pibrozelesin alkylates DNA by binding to adenine-thymine (A-T)-rich sequences in the minor groove of DNA, thereby inhibiting DNA replication and inducing apoptosis. (NCI Thesaurus)

YOU MAY ALSO LIKE

Pibenzimol

A fluorescent dye of benzimidazole derivative. Pibenzimol binds to AT-specific sites in the minor groove of duplex DNA and inhibits topoisomerase…

PIAS3 wt Allele

Human PIAS3 wild type allele is located in the vicinity of 1q21 and is approximately 11 kb in length. This allele, which…

PIAS3 Gene

This gene is involved in transcriptional coregulation and protein degradation.

PIAS1 wt Allele

Human PIAS1 wild-type allele is located in the vicinity of 15q23 and is approximately 137 kb in length. This allele, which encodes…

PIAS1 Gene

This gene is involved in both signal transduction and the sumoylation of proteins.

Pia Mater

The delicate, highly vascular, innermost membrane encasing the brain and spinal cord.