Health / Medical Topics |
Plasmid Encoding Antiangiogenic Metargidin Peptide
A plasmid encoding the protein antiangiogenic metargidin plasmid (AMEP), the disintegrin domain of ADAM-15 (metargidin), with potential antiangiogenic and antimetastatic activities. Upon intratumoral electrotransfer of plasmid encoding AMEP, AMEP binds to cellular integrin receptors alpha-v-beta-3 (avb3) and alpha-5-beta-1 (a5b1), which are upregulated on activated endothelial cells and a variety of tumor cells. Binding to the integrin receptors may inhibit angiogenesis and may inhibit tumor cell proliferation. (NCI Thesaurus)
YOU MAY ALSO LIKE

A plasmid especially designed for cloning of DNA or construction of recombinant DNA molecules. Such a cloning vector will usually have…

A small cellular inclusion consisting of a ring of DNA that is not in a chromosome but is capable of autonomous…

Collection of the fluid portion of human blood for use in blood products by plasmapheresis.

The process of separating certain cells from the plasma in the blood by a machine; only the cells are returned to the…

Plasmalogens are a class of glycerophospholipids that contain one vinyl-ester linked long chain alcohol group in place of one ester-linked fatty acid…

An ether lipid in which glycerol is covalently bound to a polar phospholipid head group like choline or ethanolamine, a typical ester-linked…
