Health / Medical Topics |
Polo-like Kinase 1 Inhibitor GSK461364
A small molecule Polo-like kinase 1 (PLK1) inhibitor with potential antineoplastic activity. Polo-like kinase 1 inhibitor GSK461364 selectively inhibits Plk1, inducing selective G2/M arrest followed by apoptosis in a variety of tumor cells while causing reversible cell arrest at the G1 and G2 stage without apoptosis in normal cells. Plk1, named after the polo gene of Drosophila melanogaster, is a serine/threonine protein kinase involved in regulating mitotic spindle function in a non-ATP competitive manner. (NCI Thesaurus)
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Members of the polo subfamily of protein kinases appear to play pivotal roles in cell division and proliferation. These include mammalian Plk,…
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Any chemical compound, biological object, physical factor in a concentration or amount that adversely alters the physical, chemical, or biological properties of…
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Human POLK wild-type allele is located in the vicinity of 5q13 and is approximately 89 kb in length. This allele, which encodes…
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This gene is involved in translesion DNA synthesis.
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