| Health / Medical Topics |
PPAR Signaling Pathway
Peroxisome proliferator-activated receptors (PPARs) are nuclear hormone receptors that are activated by fatty acids and their derivatives. PPAR has three subtypes (PPARalpha, beta/delta, and gamma) showing different expression patterns in vertebrates. Each of them is encoded in a separate gene and binds fatty acids and eicosanoids. PPARalpha plays a role in the clearance of circulating or cellular lipids via the regulation of gene expression involved in lipid metabolism in liver and skeletal muscle. PPARbeta/delta is involved in lipid oxidation and cell proliferation. PPARgamma promotes adipocyte differentiation to enhance blood glucose uptake. (NCI Thesaurus/KEGG)
YOU MAY ALSO LIKE
Similar to other nuclear hormone receptors, PPAR acts as a ligand activated transcription factor. Upon binding fatty acids or hypolipidemic drugs, PPARa…
Describes a group of proteins in a cell that work together to help control how certain genes are expressed and the use…
Human PPAP2B wild-type allele is located in the vicinity of 1p32.2 and is approximately 151 kb in length. This allele, which encodes…
This gene is involved in the metabolism of diacylglycerol.
Human PPAP2A wild-type allele is located within 5q11 and is approximately 217 kb in length. This allele, which encodes lipid phosphate phosphohydrolase…
This gene is involved in lipid metabolism/transport and receptor-activated signal transduction.
