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REDOX
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I. (noun)
Sense 1
Meaning:
A reversible chemical reaction in which one reaction is an oxidation and the reverse is a reduction
Synonyms:
oxidation-reduction; oxidoreduction; redox
Classified under:
Nouns denoting natural processes
Hypernyms ("redox" is a kind of...):
chemical reaction; reaction ((chemistry) a process in which one or more substances are changed into others)
Context examples:
Nicotinamide Adenine Dinucleotide, a coenzyme, found in eukaryotic cells and is involved in many enzymatic reactions and the production of energy through redox reactions.
(NAD, NCI Thesaurus)
GSSG and GSH together play important roles in numerous redox reactions, such as those involved in the detoxification of harmful substances and free radicals, and in reactions preventing oxidative damage in erythrocytes.
(Oxiglutatione, NCI Thesaurus)
Peroxisomes are essential organelles that play a key role in redox signaling and lipid homeostasis.
(Peroxisome Biogenesis Pathway, NCI Thesaurus/KEGG)
In addition, reactive oxygen species may form during redox cycling which may contribute to this agent's cytotoxic activity.
(Carboquone, NCI Thesaurus)
Dichloroallyl lawsone inhibits mitochondrial dihydroorotate dehydrogenase (DHOD), an enzyme that catalyzes the only redox step in de novo pyrimidine biosynthesis, and nucleotide (RNA and DNA) biosynthesis.
(Dichloroallyl Lawsone, NCI Thesaurus)
The coenzyme NAD+ plays an essential role in cellular redox reactions, including the redox reaction linking the citric acid cycle and oxidative phosphorylation.
(Daporinad, NCI Thesaurus)
Although its mechanism of action is not fully elucidated, un-ionized metronidazole is readily taken up by obligate anaerobic organisms and is subsequently reduced by low-redox potential electron-transport proteins to an active, intermediate product.
(Metronidazole, NCI Thesaurus)
TrxR, overexpressed in many cancer cell types, inhibits apoptosis, promotes cell growth and survival and plays a role in resistance to chemotherapy; TrxR catalyzes the reduction of oxidized thioredoxin (Trx) and plays a central role in regulating cellular redox homeostasis.
(Auranofin, NCI Thesaurus)
With a high membrane permeability and redox potential, copper Cu 64-ATSM is preferentially taken up by hypoxic cells compared to normoxic cells; the extent of retention in tissue is inversely related to the state of tissue oxygenation allowing the quantitation of tissue hypoxia by positron emission tomography (PET).
(copper Cu 64-ATSM, NCI Thesaurus)
Mimicking endogenous GSSG, glutathione disulfide NOV-002 acts as a competitive substrate for gamma-glutamyl-transpeptidase (GGT), which may result in the S-glutathionylation of proteins, predominantly actin, a redox stress on endoplasmic reticulum (ER), and ER stress-induced apoptosis; S-glutathionylation may be stimulated by reactive oxygen species (ROS) liberated by a glutathione disulfide NOV-002-induced increase in GGT activity.
(Glutathione Disulfide NOV-002, NCI Thesaurus)
