Salmonella VNP20009

Definition 1

A genetically stable Salmonella typhimurium strain, attenuated by chromosomal deletion of the purI and msbB genes, with tumor-targeting activity. In rodent models, salmonella VNP20009 has been shown to selectively accumulate and grow in a variety of tumor types, inhibiting the growth of primary and metastatic tumors. This agent may be genetically engineered to contain transgenes that express therapeutic agents or cell surface tumor-associated antigen-specific antibodies, such as CEA-specific antibodies, which may improve its tumor targeting and therapeutic potential. (NCI Thesaurus)

Definition 2

A genetically modified Salmonella bacterium that is injected into the tumor. It is being studied for its ability to shrink solid tumors. (NCI Dictionary)

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