Library / English Dictionary

SCLEROSIS

Pronunciation (US):

(GB):

Irregular inflected form: scleroses   

 I. (noun) 

Sense 1

Meaning:

Any pathological hardening or thickening of tissue

Synonyms:

induration; sclerosis

Classified under:

Nouns denoting stable states of affairs

Hypernyms ("sclerosis" is a kind of...):

pathology (any deviation from a healthy or normal condition)

Hyponyms (each of the following is a kind of "sclerosis"):

disseminated multiple sclerosis; disseminated sclerosis; MS; multiple sclerosis (a chronic progressive nervous disorder involving loss of myelin sheath around certain nerve fibers)

ALS; amyotrophic lateral sclerosis; Lou Gehrig's disease (thickening of tissue in the motor tracts of the lateral columns and anterior horns of the spinal cord; results in progressive muscle atrophy that starts in the limbs)

arteriolosclerosis (sclerosis of the arterioles)

arterial sclerosis; arteriosclerosis; coronary-artery disease; hardening of the arteries; induration of the arteries (sclerosis of the arterial walls)

osteosclerosis (abnormal hardening or eburnation of bone)

Derivation:

sclerotic (relating to or having sclerosis; hardened)

Credits

 Context examples: 

It may be observed in patients with stroke, motor neuron disorders, cancer of the throat or mouth, head and neck injuries, Parkinson disease, and multiple sclerosis.

(Dysphagia, NCI Thesaurus)

Disruption of this sheath impairs neuronal transmission and can result in disorders such as multiple sclerosis and Guillain-Barre syndrome, among others.

(Demyelinating Disorder, NCI Thesaurus)

A standardized rating scale developed by Hohol et al in 1995, which is a self-assessment scale of functional disability in multiple sclerosis patients primarily based on ambulation.

(Disease Steps Questionnaire, NCI Thesaurus)

A variant of systemic sclerosis characterized by calcinosis, Raynaud phenomenon, esophageal motility disorders, sclerodactyly, and telangiectasia.

(CREST Syndrome, NCI Thesaurus)

An expanded GGGGCC hexanucleotide repeat in the non-coding region of the C9orf72 gene is associated with amyotrophic lateral sclerosis and frontotemporal dementia.

(C9orf72 wt Allele, NCI Thesaurus)

It is characterized by an increased sclerosis in the superior and inferior aspects of the midbody of the vertebra, resulting in the image of a duplicate vertebral body inside the normal one.

(Bone-in-Bone Sign, NCI Thesaurus)

It may be associated with apocrine changes or sclerosis.

(Breast Adenosis, NCI Thesaurus)

It results in sclerosis of the long bones and failure of the affected organs.

(Erdheim-Chester Disease, NCI Thesaurus)

There is an association between cardiac rhabdomyoma and tuberous sclerosis.

(Cardiac Rhabdomyoma, NCI Thesaurus)

Although its etiology is unknown, it has been described in patients with HIV infection and in patients with nodular sclerosis Hodgkin lymphoma affecting the thymus gland.

(Multilocular Thymic Cyst, NCI Thesaurus)