Library / English Dictionary

SENSITIZED

Pronunciation (US):

(GB):

 I. (adjective) 

Sense 1

Meaning:

Having an allergy or peculiar or excessive susceptibility (especially to a specific factor)

Example:

hypersensitive to pollen

Synonyms:

allergic; hypersensitised; hypersensitive; hypersensitized; sensitised; sensitized; supersensitised; supersensitive; supersensitized

Classified under:

Adjectives

Similar:

susceptible ((often followed by 'of' or 'to') yielding readily to or capable of)

 II. (verb) 

Sense 1

Past simple / past participle of the verb sensitize

Credits

 Context examples: 

A preparation of autologous CD8+ (cytotoxic) T-lymphocytes sensitized to cancer-testis antigen NY-ESO-1 antigen with potential immunostimulating and antineoplastic activities.

(Autologous NY-ESO-1-Melanoma-Specific CD8+ T-lymphocytes, NCI Thesaurus)

Researchers transplanted gut microbes from each of eight infant donors into groups of mice raised in a sterile environment and sensitized to milk protein—meaning the animals’ immune systems created allergic antibodies to milk.

(Gut microbes from healthy infants block milk allergy development in mice, National Institutes of Health)

Chk1 inhibitor SCH 900776 specifically binds to and inhibits Chk1, which may result in tumor cells bypassing Chk1-dependent cell cycle arrest in the S and G2/M phases to undergo DNA repair prior to entry into mitosis; tumor cells may thus be sensitized to the DNA-damaging effects of ionizing radiation and alkylating chemotherapeutic agents.

(CHK1 Inhibitor SCH 900776, NCI Thesaurus)

A population of T cells that have been sensitized to vaccine tumor antigen(s) in vivo; collected from the patient; co-stimulated with antibodies to the T-cell cell surface proteins CD3 and CD28 and expanded ex vivo; and then infused into the same patient.

(CD3/CD28 Costimulated Autologous T-Cells, NCI Thesaurus)

Infusion of gp100 peptide-sensitized autologous T-cells into the cancer patient may stimulate the host immune system to mount a cytotoxic T lymphocyte (CTL) response against gp100-positive tumor cells, thereby decreasing tumor growth.

(gp100 Peptide-sensitized Autologous T-cells (CD4+ and CD8+), NCI Thesaurus)