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SEVERE COMBINED IMMUNODEFICIENCY
| Pronunciation (US): |  | (GB): | |
I. (noun)
Sense 1
Meaning:
A congenital disease affecting T cells that can result from a mutation in any one of several different genes; children with it are susceptible to infectious disease; if untreated it is lethal within the first year or two of life
Synonyms:
SCID; severe combined immunodeficiency; severe combined immunodeficiency disease
Classified under:
Nouns denoting stable states of affairs
Hypernyms ("severe combined immunodeficiency" is a kind of...):
immunodeficiency (immunological disorder in which some part of the body's immune system is inadequate and resistance to infectious diseases is reduced)
monogenic disease; monogenic disorder (an inherited disease controlled by a single pair of genes)
Hyponyms (each of the following is a kind of "severe combined immunodeficiency"):
ADA-SCID (SCID resulting from mutation of a gene that codes for adenosine deaminase)
X-linked SCID; X-SCID (SCID in male children resulting from mutation of a gene that codes for a protein on the surface of T cells that allows them to develop a growth factor receptor)
Context examples:
Certain allelic variants of the CD3D gene cause a form of severe combined immunodeficiency (SCID) characterized by the absence of T cells but normal numbers of B cells and NK cells.
(CD3D wt Allele, NCI Thesaurus)
Mutation of the gene is associated with severe combined immunodeficiency Athabaskan type and Omenn syndrome.
(DCLRE1C wt Allele, NCI Thesaurus)
Certain allelic variants of the ADA gene are associated with adenosine deaminase deficiency which, in some cases, causes autosomal recessive severe combined immunodeficiency.
(ADA wt Allele, NCI Thesaurus)
Early transplantation of blood-forming stem cells is a highly effective treatment for infants with severe combined immunodeficiency (SCID), a group of rare, life-threatening inherited immune system disorders, a study funded by the National Institutes of Health suggests.
(Early treatment benefits infants with severe combined immunodeficiency, NIH)
