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SH2 Domain Containing Transforming Protein 1
Widely expressed as 3 isoforms, p66SHC, p52SHC and p46SHC, by human SHC1 Gene, 583-aa 63-kDa (precursor) cytoplasmic SH2 Domain Containing Transforming Protein 1 is a growth factor receptor adaptor protein containing collagen homology, SH2, SH3, and PID/PTB domains involved in many RAS mitogenic signal transduction pathways. p46, p52, and p66 differ in the N terminals. The PID domain specifically and rapidly binds to the Asn-Pro-Xaa-Tyr(P) motif of tyrosine-phosphorylated proteins. SHC1 is phosphorylated by activated growth factor receptor tyrosine kinases. p66, tyrosine phosphorylated by activated growth factor receptors, complexes with GRB2, an adaptor protein for RAS exchange factor SOS. (NCI Thesaurus)
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