| Health / Medical Topics |
Shark Cartilage Extract AE-941
Definition 1
A multifunctional antiangiogenic agent derived from shark cartilage with potential antineoplastic activity. Shark cartilage extract AE-941 competitively inhibits the binding of pro-angiogenic vascular endothelial growth factor (VEGF) to its cellular receptor, thereby inhibiting endothelial cell proliferation. This agent also inhibits matrix metalloproteinases (MMPs), stimulates tissue plasminogen activator (tPA), and activates caspase-mediated apoptotic pathways in endothelial cells. (NCI Thesaurus)
Definition 2
A substance made from shark cartilage that is being studied for its ability to prevent the growth of new blood vessels that tumors need to grow. It is a type of antiangiogenesis agent. (NCI Dictionary)
YOU MAY ALSO LIKE
A nutritional supplement gleaned from the exoskeleton of the shark. Shark cartilage inhibits metalloproteinases (MMPs) and possesses antiangiogenic and antimetastatic properties. …
The Shared Resources and Facilities of Cancer Centers are defined as centralized facilities and services that have been structured to fulfill the…
A disorder in which a delusion develops in an individual in the context of close relationship with another person who already has…
A consortium of institutions connected by a model Web-based system that both provides direct access to data related to archived specimens and…
A monoclonal antibody directed against a specific tumor-associated antigen (TAA).
A monoclonal antibody directed against a specific tumor-associated antigen (TAA).
