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SICKLE
| Pronunciation (US): |  | (GB): | |
I. (noun)
Sense 1
Meaning:
An edge tool for cutting grass or crops; has a curved blade and a short handle
Synonyms:
reap hook; reaping hook; sickle
Classified under:
Nouns denoting man-made objects
Hypernyms ("sickle" is a kind of...):
edge tool (any cutting tool with a sharp cutting edge (as a chisel or knife or plane or gouge))
Meronyms (parts of "sickle"):
haft; helve (the handle of a weapon or tool)
II. (verb)
Sense 1
Present simple (first person singular and plural, second person singular and plural, third person plural) of the verb sickle
Context examples:
Alteration in the expression of this gene is associated with cholangiocarcinoma, acute myeloid leukemia and sickle cell disease.
(MIR320A wt Allele, NCI Thesaurus)
There are scant crops and few beeves in the borderland, where a man must reap his grain with sickle in one fist and brown bill in the other.
(The White Company, by Sir Arthur Conan Doyle)
Doctors use these transplants to treat people with certain diseases, such as: • Leukemia • Severe blood diseases such as thalassemias, aplastic anemia, and sickle cell anemia • Multiple myeloma • Certain immune deficiency diseases
(Bone Marrow Transplantation, NIH: National Heart, Lung, and Blood Institute)
Conditions that may lead to anemia include: • Heavy periods • Pregnancy • Ulcers • Colon polyps or colon cancer • Inherited disorders • A diet that does not have enough iron, folic acid or vitamin B12 • Blood disorders such as sickle cell anemia and thalassemia, or cancer • Aplastic anemia, a condition that can be inherited or acquired • G6PD deficiency, a metabolic disorder
(Anemia, NIH: National Heart, Lung, and Blood Institute)
A division of the National Heart, Lung, and Blood Institute that supports research on the causes, prevention, and treatment of nonmalignant blood diseases, including anemias, sickle cell disease, and thalassemia; premalignant processes such as myelodysplasia and myeloproliferative disorders; hemophilia and other abnormalities of hemostasis and thrombosis; and immune dysfunction.
(Division of Blood Diseases and Resources, NCI Thesaurus)
A hemoglobinopathy that is considered a hybrid of sickle cell disease and hemoglobin C disease.
(Hemoglobin SC Disease, NCI Thesaurus)
Thirty patients, ages 16 to 65, with severe sickle cell disease enrolled in the study between 2004 and 2013.
(Stem cell transplant reverses sickle cell disease in adults, NIH)
Sickle cell disease is an inherited blood disorder.
(Stem cell transplant reverses sickle cell disease in adults, NIH)
Despite the mix, sickle cell disease was reversed.
(Stem cell transplant reverses sickle cell disease in adults, NIH)
Based in part on these findings in children, as well as other preliminary work, a team at NIH’s Clinical Center in Bethesda, Maryland, set out to test a modified transplant procedure in adults with sickle cell disease.
(Stem cell transplant reverses sickle cell disease in adults, NIH)
