Siltuximab

Pronunciation

Definition 1

A human-mouse chimeric antibody, constructed from a murine anti-interleukin 6 (IL-6) monoclonal antibody, with antitumor and anti-inflammatory activities. Containing the antigen-binding variable region of the murine antibody, CLB-IL-6-8, and the constant region of a human IgG1kappa immunoglobulin, anti-IL-6 chimeric monoclonal antibody has high affinity for recombinant as well as native IL-6 and inhibits the binding of IL-6 to the IL-6 receptor (IL-6R), resulting in the blockade of the IL-6/IL-6R/gp130 signal transduction pathway, and, subsequently, antitumor and anti-inflammatory activities. (NCI Thesaurus)

Definition 2

A chimeric (made from human and mouse proteins) monoclonal antibody being studied in the treatment of advanced kidney cancer and other types of cancer. Monoclonal antibodies are made in the laboratory and can locate and bind to substances in the body, including cancer cells. Anti-IL-6 chimeric monoclonal antibody works by blocking inflammation and tumor growth. (NCI Dictionary)

YOU MAY ALSO LIKE

Silo

A repository of customized concept terminology data from a knowledgebase.

Silmitasertib Sodium

The sodium salt of silmitasertib, an orally bioavailable small-molecule inhibitor of CK2 with potential antineoplastic activity. Silmitasertib selectively binds to and inhibits…

Silky Terrier

The Silky Terrier is a fine-boned, moderately low-set, long-haired terrier. It is compact but lightly built with erect, v-shaped ears. It has…

Silk

The styles (the filamentous structure of a flower that supports the pollen-containing anthers) on an ear of corn.

Silicosis

An occupational lung disorder caused by the inhalation of silica dust. It results in the inflammation and scarring of the upper lobes…

Silicone

A synthetic gel that is used as an outer coating on breast implants and as the inside filling of some implants. …