Simmitecan Hydrochloride

The hydrochloride salt form of simmitecan, an ester prodrug of chimmitecan, a 9-alkyl substituted camptothecin derivative with potential antineoplastc activity. Upon intravenous administration, simmitecan is hydrolyzed by carboxylesterase and the activated form, chimmitecan, is produced. Chimmitecan inhibits topoisomerase I, stabilizes covalent topoisomerase I-DNA complexes, and inhibits the religation of topoisomerase I-mediated single-strand DNA breaks. Futhermore, the covalent topoisomerase I-DNA complexes interfere and block the DNA replication machinery, resulting in the production of potentially lethal double-strand DNA breaks. This leads to an inhibition of DNA replication and the induction of apoptosis. The modification at position 9 yields improved cytotoxicity compared to some other camptothecin analogues. (NCI Thesaurus)

YOU MAY ALSO LIKE

Similarity

The quality of being alike; having characteristics in common.

Simian virus 40

A virus that infects some types of monkeys. It may also infect humans, and was found in some polio vaccines tested in…

Simian T-Lymphotropic Virus Type I

A single-stranded reverse-transcribing RNA retrovirus of the genus deltaretrovirus that infects a wide range of non-human primates.

Simian Immunodeficiency Virus

An HIV-like virus that infects monkeys, chimpanzees, and other non-human primates. (AIDS Info HIV Glossary)

Simfibrate

A derivative of clofibrate with antilipidemic activity.

Simethicone

A mixture of polydimethylsiloxanes with antifoaming and anti-bloating effects. Simethicone reduces the surface tension of gas bubbles causing them to coalesce into…