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Sorivudine
Pronunciation
Definition 1
An antiviral drug that is being studied as a treatment for herpesvirus. It belongs to the family of drugs called nucleic acid synthesis inhibitors. (NCI Dictionary)
Definition 2
A synthetic thymidine analogue with potent antiviral activity against herpes simplex and varicella zoster viruses. Sorivudine is phosphorylated into triphosphate form within the cells; this metabolite interferes with viral DNA replication by inhibiting DNA polymerase activity without been incorporated into elongating viral DNA. Due to the dangerous effects of drug-drug interactions via its metabolite, sorivudine has been removed from the market. (NCI Thesaurus)
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