Stanniocalcin 2

Widely expressed in muscle and heart (strongest), pancreas, kidney, spleen, prostate, small intestine, colon, and peripheral leucocytes by human STC2 Gene (Stanniocalcin Family) at 5q35.2 encodes 302-aa Stanniocalcin 2, a constitutively secreted disulfide-linked homodimeric 32-kD protein that regulates calcium and phosphate homeostasis. STC2 shares 34% identity with STC1; human and mouse proteins are nearly 88% identical. A Cys-rich N-terminal region may mediate homodimerization. STC2 function on kidney phosphate transport appears to be opposite STC1. STC2 may be serine phosphorylated by a casein kinase-2 ecto-protein. STC2 is likely phosphorylated on serine 288. Phosphorylation may regulate calcium and phosphate homeostasis activity. (NCI Thesaurus)

YOU MAY ALSO LIKE

Stanniocalcin 1

Expressed in most tissues (ovary, prostate, heart, kidney, and thyroid highest) by human STC1 Gene (Stanniocalcin Family), 247-aa 28-kDa (precursor) secreted Stanniocalcin…

Stanford V regimen

An abbreviation for a chemotherapy combination that is used to treat Hodgkin lymphoma and is being studied in the treatment of other…

Stanford V

An abbreviation for a chemotherapy combination that is used to treat Hodgkin lymphoma and is being studied in the treatment of other…

Stanford Cancer Institute

The Stanford Cancer Institute is focused on improving the diagnosis, treatment, and outcomes for cancer patients, understanding cancer etiologies among diverse populations,…

Stanford Binet Intelligence Test

A standardized test to evaluate intelligence and cognitive abilities, suitable for both children and adults. It assesses five factors: Fluid Reasoning, Knowledge,…

Standing

The act of assuming or maintaining an erect upright position.