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STATIN
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I. (noun)
Sense 1
Meaning:
A medicine that lowers blood cholesterol levels by inhibiting HMG-CoA reductase
Synonyms:
lipid-lowering medication; lipid-lowering medicine; statin; statin drug
Classified under:
Nouns denoting man-made objects
Hypernyms ("statin" is a kind of...):
medicament; medication; medicinal drug; medicine ((medicine) something that treats or prevents or alleviates the symptoms of disease)
Hyponyms (each of the following is a kind of "statin"):
atorvastatin; Lipitor (an oral drug (trade name Lipitor) that is effective in lowering triglycerides; potent in reducing LDL cholesterol because higher doses can be given)
Baycol; cerivastatin (an oral drug (trade name Baycol) to reduce blood cholesterol levels)
fluvastatin; Lescol (least expensive statin drug (trade name Lescol); usually taken orally at bedtime)
lovastatin; Mevacor (an oral drug (trade name Mevacor) to reduce blood cholesterol levels; used when dietary changes have proved inadequate)
Pravachol; pravastatin (an oral drug (trade name Pravachol) administered to reduce blood cholesterol levels; recommended after nonfatal heart attacks)
simvastatin; Zocor (an oral lipid-lowering medicine (trade name Zocor) administered to reduce blood cholesterol levels; recommended after heart attacks)
Context examples:
However, statins also give rise to the body forming more of a harmful protein — known as PCSK9 — which counters the effect of the statins.
(Discovery Can Pave the Way for More Effective Cholesterol Medicine, The Titi Tudorancea Bulletin)
The statins such as lovastatin are drugs that inhibit cholesterol biosynthesis, lowering intracellular cholesterol levels and activating SREBP cleavage to increase LDLR expression on the cell surface.
(Lipid Synthesis Pathway, NCI Thesaurus/BIOCARTA)
A calcium salt formulation of pitavastatin, a novel statin that induces plaque regression and elevates HDL-cholesterol levels.
(Pitavastatin Calcium, NCI Thesaurus)
Lovastatin is a type of HMG-CoA reductase inhibitor (statin).
(Lovastatin, NCI Dictionary)
Mevacor is a type of HMG-CoA reductase inhibitor (statin).
(Mevacor, NCI Dictionary)
A class of agents, other than statins, that are capable of inhibiting absorption of cholesterol, reducing the production and release of LDL from the liver, the release of free fatty acids stored in fat cells, or reducing the production of triglycerides.
(Non-Statin Antilipidemic Agent, NCI Thesaurus)
Through the inhibition of mevalonate synthesis, statins, like fluvastatin, have been shown to inhibit the production of dolichol, geranylpyrophosphate (GPP) and farnesylpyrophosphate (FPP) and the isoprenylation of the intracellular G-proteins Ras and Rho, which may result in antiangiogenic, apoptotic, and antimetastatic effects in susceptible tumor cell populations.
(Fluvastatin Sodium, NCI Thesaurus)
Like other statins, atorvastatin may also display direct antineoplastic activity, possibly by inhibiting farnesylation and geranylgeranylation of proteins such as small GTP-binding proteins, which may result in the arrest of cells in the G1 phase of the cell cycle.
(Atorvastatin calcium, NCI Thesaurus)
One problem is interactions, which may occur between: • Two drugs, such as aspirin and blood thinners • Drugs and food, such as statins and grapefruit • Drugs and supplements, such as gingko and blood thinners • Drugs and diseases, such as aspirin and peptic ulcers
(Drug Reactions, NIH)
Aspirin is a cyclooxygenase inhibitor with antiplatelet, analgesic, antipyretic and anti-inflammatory activities; simvastatin is a statin with a cholesterol lowering effect; and the beta-blocker atenolol as well as the ACE inhibitor ramipril and the thiazide diuretic all have blood pressure lowering activity.
(Aspirin/Simvastatin/Atenolol/Ramipril/Thiazide Capsule, NCI Thesaurus)
