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SYSTEMIC LUPUS ERYTHEMATOSUS
| Pronunciation (US): |  | (GB): | |
I. (noun)
Sense 1
Meaning:
An inflammatory disease of connective tissue with variable features including fever and weakness and fatigability and joint pains and skin lesions on the face or neck or arms
Synonyms:
disseminated lupus erythematosus; SLE; systemic lupus erythematosus
Classified under:
Nouns denoting stable states of affairs
Hypernyms ("systemic lupus erythematosus" is a kind of...):
lupus (any of several forms of ulcerative skin disease)
Context examples:
Variants include discoid and systemic lupus erythematosus.
(Lupus Erythematosus, NCI Thesaurus)
Also called SLE and systemic lupus erythematosus.
(Lupus, NCI Dictionary)
Variant alleles generated from mutations in the gene, have been associated with insulin-dependent diabetes mellitus, Graves disease, Hashimoto thyroiditis, celiac disease, systemic lupus erythematosus, thyroid-associated orbitopathy, and other autoimmune diseases.
(CTLA4 wt Allele, NCI Thesaurus)
An autoimmune overlap syndrome characterized by the presence of symptoms of systemic lupus erythematosus, systemic scleroderma, and polymyositis.
(Mixed Connective Tissue Disease, NCI Thesaurus)
A term previously used to describe chronic diseases of the connective tissue (e.g., rheumatoid arthritis, systemic lupus erythematosus, and systemic sclerosis), but now is thought to be more appropriate for diseases associated with defects in collagen, which is a component of the connective tissue.
(Collagen disease, NCI Dictionary)
Historically, a heterogeneous group of acute and chronic diseases, including rheumatoid arthritis, systemic lupus erythematosus, progressive systemic sclerosis, dermatomyositis, etc. This classification was based on the notion that collagen was equivalent to connective tissue, but with the present recognition of the different types of collagen and the aggregates derived from them as distinct entities, the term collagen diseases now pertains exclusively to those inherited conditions in which the primary defect is at the gene level and affects collagen biosynthesis, post-translational modification, or extracellular processing directly.
(Collagen disease, NLM, Medical Subject Headings)
Infection with Epstein-Barr virus (EBV), the cause of infectious mononucleosis, has been associated with subsequent development of systemic lupus erythematosus and other chronic autoimmune illnesses, but the mechanisms behind this association have been unclear.
(Epstein-Barr virus protein can “switch on” risk genes for autoimmune diseases, National Institutes of Health)
Pathologic Ab-Ig Proteins are immunoglobulin-related (IgA, IgD, IgE, IgG, IgM antibody) glycoproteins characteristically found in patients with multiple myeloma, infectious diseases, rheumatoid arthritis and other connective tissue diseases, or systemic autoimmune diseases including systemic lupus erythematosus, Sjogren's syndrome, scleroderma, polymyositis, and mixed connective tissue disease.
(Pathologic Ab-Ig Protein, NCI Thesaurus)
A painful asymmetric asynchronous sensory and motor peripheral neuropathy involving isolated damage to at least 2 separate nerve areas; associated with (but not limited to) systemic disorders such as diabetes, vasculitis, amyloidosis, direct tumor involvement, polyarteritis nodosa, rheumatoid arthritis, systemic lupus erythematosus, and paraneoplastic syndromes.
(Mononeuritis Multiplex, NCI Thesaurus)
