Health / Medical Topics

    T-Cell Differentiation in the Thymus

    The progression of T cell precursors in the thymus through many stages of maturation. These stages include regulated expression of the alpha and beta (or gamma and delta) chains of the T cell receptor, expression of both CD4 and CD8 molecules (double positive stage), down regulation to a single positive stage (CD4 or CD8), as well as allowing those thymocytes to die which are unable to bind to self MHC molecules (death by neglect), selecting those thymocytes with T Cell Receptors that are able to bind to self MHC molecules with moderate affinity (positive selection), and deleting those thymocytes having T Cell Receptors that bind with high affinity to self MHC (negative selection), before allowing mature T cells to emigrate to the periphery. (NCI Thesaurus)




    YOU MAY ALSO LIKE

    T-cell differentiation antigen CD6 (668 aa, ~72 kDa) is encoded by the human CD6 gene. This protein plays a role in the…
    Development of bone marrow-derived stem cells in the thymus through stages of positive selection under the influence of epithelial cells in the…
    Treatment to destroy T cells, which play an important role in the immune response. Elimination of T cells from a bone marrow…
    Treatment to destroy T cells, which play an important role in the immune response. Elimination of T cells from a bone marrow…
    A slow-growing type of leukemia (blood cancer) in which too many lymphocytes are found in the bone marrow and/or blood. The…
    Mef2 (Myocyte enhancer factor 2) transcription factors play a role in T-Cell calcium induced apoptosis. Several factors regulate Mef2 transcription factors, including…

    © 1991-2023 The Titi Tudorancea Bulletin | Titi Tudorancea® is a Registered Trademark | Terms of use and privacy policy
    Contact